ENSMUSG00000078566


Mus musculus

Features
Gene ID: ENSMUSG00000078566
  
Biological name :Bnip3
  
Synonyms : BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 / Bnip3 / O55003
  
Possible biological names infered from orthology : BCL2 interacting protein 3 / Q12983
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F4
Gene start: 138890836
Gene end: 138909519
  
Corresponding Affymetrix probe sets: 10414269 (MoGene1.0st)   10568785 (MoGene1.0st)   1422470_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148170
Ensembl peptide - ENSMUSP00000101718
NCBI entrez gene - 12176     See in Manteia.
MGI - MGI:109326
RefSeq - NM_009760
RefSeq Peptide - NP_033890
swissprot - A0A1B0GT26
swissprot - O55003
Ensembl - ENSMUSG00000078566
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bnip3ENSDARG00000099961Danio rerio
 bnip4ENSDARG00000022832Danio rerio
 BNIP3ENSGALG00000010476Gallus gallus
 BNIP3ENSG00000176171Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bnip3l / Q9Z2F7 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like / O60238* / BCL2 interacting protein 3 like*ENSMUSG0000002205159


Protein motifs (from Interpro)
Interpro ID Name
 IPR010548  BNIP3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway IEA
 biological_processGO:0010637 negative regulation of mitochondrial fusion IEA
 biological_processGO:0010659 cardiac muscle cell apoptotic process IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010821 regulation of mitochondrion organization IMP
 biological_processGO:0010917 negative regulation of mitochondrial membrane potential IEA
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0035694 mitochondrial protein catabolic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0043243 positive regulation of protein complex disassembly IEA
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IEA
 biological_processGO:0045837 negative regulation of membrane potential IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0048102 autophagic cell death IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071279 cellular response to cobalt ion IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0090141 positive regulation of mitochondrial fission IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IEA
 biological_processGO:1901998 toxin transport IMP
 biological_processGO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process IEA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IEA
 biological_processGO:1903715 regulation of aerobic respiration IMP
 biological_processGO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005740 mitochondrial envelope IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lgr5tm1Ah/Lgr5tm1Ah
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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