ENSMUSG00000022051


Mus musculus

Features
Gene ID: ENSMUSG00000022051
  
Biological name :Bnip3l
  
Synonyms : BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like / Bnip3l / Q9Z2F7
  
Possible biological names infered from orthology : BCL2 interacting protein 3 like / O60238
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 66985239
Gene end: 67008877
  
Corresponding Affymetrix probe sets: 10394800 (MoGene1.0st)   10421003 (MoGene1.0st)   1416922_a_at (Mouse Genome 430 2.0 Array)   1416923_a_at (Mouse Genome 430 2.0 Array)   1448525_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022634
Ensembl peptide - ENSMUSP00000106744
NCBI entrez gene - 12177     See in Manteia.
MGI - MGI:1332659
RefSeq - XM_017315807
RefSeq - NM_009761
RefSeq - XM_006518471
RefSeq Peptide - NP_033891
swissprot - Q9Z2F7
swissprot - Q91Z78
Ensembl - ENSMUSG00000022051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bnip3laENSDARG00000025468Danio rerio
 bnip3lbENSDARG00000028067Danio rerio
 BNIP3LENSGALG00000043405Gallus gallus
 BNIP3LENSG00000104765Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bnip3 / O55003 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 / Q12983* / BCL2 interacting protein 3*ENSMUSG0000007856651


Protein motifs (from Interpro)
Interpro ID Name
 IPR010548  BNIP3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010917 negative regulation of mitochondrial membrane potential IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0035694 mitochondrial protein catabolic process IEA
 biological_processGO:0035794 positive regulation of mitochondrial membrane permeability IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043069 negative regulation of programmed cell death IBA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IBA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IGI
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005740 mitochondrial envelope IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISO
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005521 lamin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
Show

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Smad4tm3Rob/Smad4tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad4tm3Rob/Smad4tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

Allelic Composition: Bbc3tm1Gpz/Bbc3tm1Gpz,Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Bnip3lGt(XT0573)Wtsi/Bnip3lGt(XT0573)Wtsi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm2Holl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bnip3ltm1Gwd/Bnip3ltm1Gwd,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cd47tm1Fpl/Cd47tm1Fpl
Genetic Background: B6.129S7-Cd47tm1Fpl

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0011177 abnormal erythroblast number "altered number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Bnip3ltm1.1Gwd/Bnip3ltm1.1Gwd
Genetic Background: involves: 129 * C57BL/6

 MP:0014046 abnormal mitophagy "any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [MGI:Anna, PMID:22743996]
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Allelic Composition: Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026389 Steap3 / STEAP family member 3 / Q658P3* / STEAP3 metalloreductase*  / complex / reaction






 

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