ENSMUSG00000026389


Mus musculus

Features
Gene ID: ENSMUSG00000026389
  
Biological name :Steap3
  
Synonyms : Steap3 / STEAP family member 3
  
Possible biological names infered from orthology : Q658P3 / STEAP3 metalloreductase
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 120190757
Gene end: 120272705
  
Corresponding Affymetrix probe sets: 10357249 (MoGene1.0st)   1423468_at (Mouse Genome 430 2.0 Array)   1430355_a_at (Mouse Genome 430 2.0 Array)   1453498_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108259
Ensembl peptide - ENSMUSP00000121046
Ensembl peptide - ENSMUSP00000108262
Ensembl peptide - ENSMUSP00000108260
Ensembl peptide - ENSMUSP00000108258
NCBI entrez gene - 68428     See in Manteia.
MGI - MGI:1915678
RefSeq - XM_006529846
RefSeq - NM_001085409
RefSeq - NM_133186
RefSeq - XM_006529845
RefSeq Peptide - NP_001078878
RefSeq Peptide - NP_573449
swissprot - E9QN92
swissprot - A0A0R4J1G9
swissprot - D3YTP0
Ensembl - ENSMUSG00000026389
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 steap3ENSDARG00000075641Danio rerio
 STEAP3ENSGALG00000012117Gallus gallus
 Q658P3ENSG00000115107Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BWB6 / Steap2 / six transmembrane epithelial antigen of prostate 2 / Q8NFT2* / STEAP2 metalloreductase*ENSMUSG0000001565353
Q923B6 / Steap4 / Metalloreductase STEAP4 / Q687X5* / STEAP4 metalloreductase*ENSMUSG0000001242842
Steap1 / Q9CWR7 / Metalloreductase STEAP1 / Q9UHE8* / Q6NZ63* / STEAP1B* / STEAP family member 1* / STEAP family member 1B*ENSMUSG0000001565229


Protein motifs (from Interpro)
Interpro ID Name
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009306 protein secretion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Transferrin endocytosis and recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Cd3gtm1.1Cage/Cd3gtm1.1Cage,Tg(TcrLCMV)318Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

 MP:0002424 abnormal reticulocyte morphology/development "anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0003066 increased hepatic copper content "a greater accumulation of copper in the liver tissue compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0006349 decreased circulating copper level "less than the normal concentration of copper in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]
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Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0008996 abnormal blood osmolality "increase in the concentration of ions in the blood or blood fractions compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0009341 decreased splenocyte apoptosis "reduction in the number of spleen cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Steap3tm1.1Atel/Steap3tm1.1Atel
Genetic Background: involves: C57BL/6

 MP:0010175 leptocytosis "the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull s-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022051 Bnip3l / Q9Z2F7 / BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like / O60238* / BCL2 interacting protein 3 like*  / complex / reaction






 

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