ENSG00000177556


Homo sapiens

Features
Gene ID: ENSG00000177556
  
Biological name :ATOX1
  
Synonyms : antioxidant 1 copper chaperone / ATOX1 / O00244
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q33.1
Gene start: 151742316
Gene end: 151772532
  
Corresponding Affymetrix probe sets: 203454_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429814
Ensembl peptide - ENSP00000430598
Ensembl peptide - ENSP00000430028
Ensembl peptide - ENSP00000429982
Ensembl peptide - ENSP00000316854
Ensembl peptide - ENSP00000429366
NCBI entrez gene - 475     See in Manteia.
OMIM - 602270
RefSeq - NM_004045
RefSeq Peptide - NP_004036
swissprot - E5RIM7
swissprot - E5RGN3
swissprot - O00244
Ensembl - ENSG00000177556
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atox1ENSDARG00000087693Danio rerio
 ATOX1ENSGALG00000004176Gallus gallus
 Atox1ENSMUSG00000018585Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006121  Heavy metal-associated domain, HMA
 IPR017969  Heavy-metal-associated, conserved site
 IPR036163  Heavy metal-associated domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006825 copper ion transport TAS
 biological_processGO:0006878 cellular copper ion homeostasis TAS
 biological_processGO:0006979 response to oxidative stress IBA
 biological_processGO:0015680 intracellular copper ion transport IBA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0035434 copper ion transmembrane transport IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005375 copper ion transmembrane transporter activity IEA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016530 metallochaperone activity TAS
 molecular_functionGO:0016531 copper chaperone activity IDA
 molecular_functionGO:0032767 copper-dependent protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
Ion influx/efflux at host-pathogen interface


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120509 PDZD11 / Q5EBL8 / PDZ domain containing 11  / reaction
 ENSG00000165240 ATP7A / Q04656 / ATPase copper transporting alpha  / reaction






 

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