ENSG00000178896


Homo sapiens

Features
Gene ID: ENSG00000178896
  
Biological name :EXOSC4
  
Synonyms : EXOSC4 / exosome component 4 / Q9NPD3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.3
Gene start: 144078626
Gene end: 144080647
  
Corresponding Affymetrix probe sets: 218695_at (Human Genome U133 Plus 2.0 Array)   58696_at (Human Genome U133 Plus 2.0 Array)   91684_g_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000315476
Ensembl peptide - ENSP00000436539
Ensembl peptide - ENSP00000432661
NCBI entrez gene - 54512     See in Manteia.
OMIM - 606491
RefSeq - NM_019037
RefSeq - XM_011517134
RefSeq Peptide - NP_061910
swissprot - E9PPI9
swissprot - Q9NPD3
swissprot - E9PI41
Ensembl - ENSG00000178896
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc4ENSDARG00000103432Danio rerio
 Exosc4ENSMUSG00000034259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EXOSC6 / Q5RKV6 / exosome component 6ENSG0000022349629


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000460 maturation of 5.8S rRNA IMP
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IMP
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0016075 rRNA catabolic process IBA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0031125 rRNA 3"-end processing IBA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
 biological_processGO:0045006 DNA deamination IDA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0071028 nuclear mRNA surveillance IMP
 biological_processGO:0071044 histone mRNA catabolic process IMP
 biological_processGO:0071051 polyadenylation-dependent snoRNA 3"-end processing IBA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0035327 transcriptionally active chromatin IMP
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity NAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IDA


Pathways (from Reactome)
Pathway description
ATF4 activates genes
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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