ENSMUSG00000034259


Mus musculus

Features
Gene ID: ENSMUSG00000034259
  
Biological name :Exosc4
  
Synonyms : Exosc4 / Exosome complex component RRP41 / Q921I9
  
Possible biological names infered from orthology : exosome component 4 / Q9NPD3
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 76327397
Gene end: 76330677
  
Corresponding Affymetrix probe sets: 10424804 (MoGene1.0st)   1424685_at (Mouse Genome 430 2.0 Array)   1437712_x_at (Mouse Genome 430 2.0 Array)   1460679_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050940
Ensembl peptide - ENSMUSP00000155254
NCBI entrez gene - 109075     See in Manteia.
MGI - MGI:1923576
RefSeq - NM_175399
RefSeq Peptide - NP_780608
swissprot - Q542B0
swissprot - Q921I9
Ensembl - ENSMUSG00000034259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc4ENSDARG00000103432Danio rerio
 EXOSC4ENSG00000178896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Exosc6 / Q8BTW3 / Exosome complex component MTR3 / Q5RKV6* / exosome component 6*ENSMUSG0000010994129


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000460 maturation of 5.8S rRNA IEA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0016075 rRNA catabolic process IBA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031125 rRNA 3"-end processing IBA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0045006 DNA deamination ISO
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071044 histone mRNA catabolic process IEA
 biological_processGO:0071051 polyadenylation-dependent snoRNA 3"-end processing IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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