ENSMUSG00000109941


Mus musculus

Features
Gene ID: ENSMUSG00000109941
  
Biological name :Exosc6
  
Synonyms : Exosc6 / Exosome complex component MTR3 / Q8BTW3
  
Possible biological names infered from orthology : exosome component 6 / Q5RKV6
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 111056339
Gene end: 111057664
  
Corresponding Affymetrix probe sets: 1429322_at (Mouse Genome 430 2.0 Array)   1435544_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147696
NCBI entrez gene - 72544     See in Manteia.
MGI - MGI:1919794
RefSeq - NM_028274
RefSeq Peptide - NP_082550
swissprot - Q8BTW3
Ensembl - ENSMUSG00000109941
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc6ENSDARG00000036060Danio rerio
 EXOSC6ENSG00000223496Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Exosc4 / Q921I9 / Exosome complex component RRP41 / Q9NPD3* / exosome component 4*ENSMUSG0000003425926


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0016075 rRNA catabolic process IBA
 biological_processGO:0031125 rRNA 3"-end processing IBA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0045006 DNA deamination IEA
 biological_processGO:0045190 isotype switching IMP
 biological_processGO:0045830 positive regulation of isotype switching IMP
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071051 polyadenylation-dependent snoRNA 3"-end processing IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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