ENSG00000183207


Homo sapiens

Features
Gene ID: ENSG00000183207
  
Biological name :RUVBL2
  
Synonyms : Q9Y230 / RUVBL2 / RuvB like AAA ATPase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 48993448
Gene end: 49015995
  
Corresponding Affymetrix probe sets: 1559945_at (Human Genome U133 Plus 2.0 Array)   1559946_s_at (Human Genome U133 Plus 2.0 Array)   201459_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486242
Ensembl peptide - ENSP00000473172
Ensembl peptide - ENSP00000492564
Ensembl peptide - ENSP00000492610
Ensembl peptide - ENSP00000221413
Ensembl peptide - ENSP00000469189
Ensembl peptide - ENSP00000469488
Ensembl peptide - ENSP00000469760
Ensembl peptide - ENSP00000471524
Ensembl peptide - ENSP00000471538
NCBI entrez gene - 10856     See in Manteia.
OMIM - 604788
RefSeq - XM_011526330
RefSeq - NM_001321190
RefSeq - NM_001321191
RefSeq - NM_006666
RefSeq Peptide - NP_001308119
RefSeq Peptide - NP_001308120
RefSeq Peptide - NP_006657
swissprot - Q9Y230
swissprot - X6R2L4
swissprot - A0A1W2PS22
swissprot - A0A1W2PS48
swissprot - M0QXI6
swissprot - M0QYD8
swissprot - M0QXZ7
swissprot - M0R0Y3
swissprot - M0R0Z0
Ensembl - ENSG00000183207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P83571ENSDARG00000055639Danio rerio
 Q9WTM5ENSMUSG00000003868Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010339  TIP49, C-terminal
 IPR027238  RuvB-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000492 box C/D snoRNP assembly IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0034644 cellular response to UV IMP
 biological_processGO:0035066 positive regulation of histone acetylation IMP
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043967 histone H4 acetylation IDA
 biological_processGO:0043968 histone H2A acetylation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0071169 establishment of protein localization to chromatin IMP
 biological_processGO:0071392 cellular response to estradiol stimulus IMP
 biological_processGO:0071733 transcriptional activation by promoter-enhancer looping IMP
 biological_processGO:0071899 negative regulation of estrogen receptor binding IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body IMP
 cellular_componentGO:0000812 Swr1 complex IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071339 MLL1 complex IDA
 cellular_componentGO:0097255 R2TP complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001094 TFIID-class transcription factor binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0017025 TBP-class protein binding IDA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0051082 unfolded protein binding TAS
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Telomere Extension By Telomerase
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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