ENSMUSG00000003868


Mus musculus

Features
Gene ID: ENSMUSG00000003868
  
Biological name :Ruvbl2
  
Synonyms : Q9WTM5 / Ruvbl2 / RuvB-like protein 2
  
Possible biological names infered from orthology : Q9Y230 / RuvB like AAA ATPase 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45421760
Gene end: 45438096
  
Corresponding Affymetrix probe sets: 10563275 (MoGene1.0st)   1422482_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147423
Ensembl peptide - ENSMUSP00000148205
Ensembl peptide - ENSMUSP00000148040
Ensembl peptide - ENSMUSP00000147688
Ensembl peptide - ENSMUSP00000147650
Ensembl peptide - ENSMUSP00000147502
Ensembl peptide - ENSMUSP00000103400
NCBI entrez gene - 20174     See in Manteia.
MGI - MGI:1342299
RefSeq - XM_006540723
RefSeq - NM_011304
RefSeq - XM_006540722
RefSeq Peptide - NP_035434
swissprot - A0A1B0GSR4
swissprot - A0A1B0GT54
swissprot - Q3TXT7
swissprot - Q9WTM5
swissprot - A0A1B0GRW3
swissprot - A0A1B0GR89
swissprot - A0A1B0GRT1
Ensembl - ENSMUSG00000003868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P83571ENSDARG00000055639Danio rerio
 Q9Y230ENSG00000183207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR010339  TIP49, C-terminal
 IPR012340  Nucleic acid-binding, OB-fold
 IPR027238  RuvB-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000492 box C/D snoRNP assembly IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016573 histone acetylation IBA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0034644 cellular response to UV ISO
 biological_processGO:0035066 positive regulation of histone acetylation ISO
 biological_processGO:0043967 histone H4 acetylation ISO
 biological_processGO:0043968 histone H2A acetylation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0071169 establishment of protein localization to chromatin ISO
 biological_processGO:0071392 cellular response to estradiol stimulus ISO
 biological_processGO:0071733 transcriptional activation by promoter-enhancer looping ISO
 biological_processGO:0071899 negative regulation of estrogen receptor binding ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body ISO
 cellular_componentGO:0000812 Swr1 complex ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005719 nuclear euchromatin ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 cellular_componentGO:0071339 MLL1 complex ISO
 cellular_componentGO:0097255 R2TP complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0001094 TFIID-class transcription factor binding IPI
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0031490 chromatin DNA binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IEA
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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