ENSG00000184956


Homo sapiens

Features
Gene ID: ENSG00000184956
  
Biological name :MUC6
  
Synonyms : MUC6 / mucin 6, oligomeric mucus/gel-forming / Q6W4X9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 1012821
Gene end: 1036706
  
Corresponding Affymetrix probe sets: 1565666_s_at (Human Genome U133 Plus 2.0 Array)   214133_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433790
Ensembl peptide - ENSP00000436903
Ensembl peptide - ENSP00000406861
Ensembl peptide - ENSP00000433246
NCBI entrez gene - 4588     See in Manteia.
OMIM - 158374
RefSeq - NM_005961
RefSeq Peptide - NP_005952
swissprot - E9PJC5
swissprot - H0YDA7
swissprot - H0YEZ6
swissprot - Q6W4X9
Ensembl - ENSG00000184956
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MUC6ENSGALG00000040530Gallus gallus
 Muc6ENSMUSG00000048191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MUC5B / Q9HC84 / mucin 5B, oligomeric mucus/gel-formingENSG0000011798330
MUC5AC / P98088 / mucin 5AC, oligomeric mucus/gel-formingENSG0000021518230
OTOG / Q6ZRI0 / otogelinENSG0000018816220
SSPO / SCO-spondinENSG0000019755820
VWF / P04275 / von Willebrand factorENSG0000011079918
OTOGL / Q3ZCN5 / otogelin likeENSG0000016589916
FCGBP / Fc fragment of IgG binding proteinENSG0000027539513
TECTA / O75443 / tectorin alphaENSG0000010992712
ZAN / zonadhesin (gene/pseudogene)ENSG0000014683912


Protein motifs (from Interpro)
Interpro ID Name
 IPR001007  VWFC domain
 IPR001846  von Willebrand factor, type D domain
 IPR002919  Trypsin Inhibitor-like, cysteine rich domain
 IPR006207  Cystine knot, C-terminal
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR030124  Mucin-6
 IPR036084  Serine protease inhibitor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0016266 O-glycan processing TAS
 biological_processGO:0030277 maintenance of gastrointestinal epithelium IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0005201 extracellular matrix structural constituent NAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Dectin-2 family
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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