ENSG00000215182


Homo sapiens

Features
Gene ID: ENSG00000215182
  
Biological name :MUC5AC
  
Synonyms : MUC5AC / mucin 5AC, oligomeric mucus/gel-forming / P98088
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.5
Gene start: 1157953
Gene end: 1201138
  
Corresponding Affymetrix probe sets: 214303_x_at (Human Genome U133 Plus 2.0 Array)   214385_s_at (Human Genome U133 Plus 2.0 Array)   217187_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485659
NCBI entrez gene - 4586     See in Manteia.
OMIM - 158373
RefSeq - NM_001304359
RefSeq Peptide - NP_001291288
swissprot - P98088
Ensembl - ENSG00000215182
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 muc5.1ENSDARG00000070331Danio rerio
 muc5.2ENSDARG00000058556Danio rerio
 muc5.3ENSDARG00000099470Danio rerio
 ENSGALG00000034144Gallus gallus
 ENSGALG00000031737Gallus gallus
 ovomucin precursor ENSGALG00000006717Gallus gallus
 Muc5acENSMUSG00000037974Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MUC5B / Q9HC84 / mucin 5B, oligomeric mucus/gel-formingENSG0000011798329
SSPO / SCO-spondinENSG0000019755814
VWF / P04275 / von Willebrand factorENSG0000011079913
MUC6 / Q6W4X9 / mucin 6, oligomeric mucus/gel-formingENSG0000018495613
OTOG / Q6ZRI0 / otogelinENSG0000018816212
OTOGL / Q3ZCN5 / otogelin likeENSG0000016589910
FCGBP / Fc fragment of IgG binding proteinENSG000002753958
TECTA / O75443 / tectorin alphaENSG000001099277
ZAN / zonadhesin (gene/pseudogene)ENSG000001468397


Protein motifs (from Interpro)
Interpro ID Name
 IPR001007  VWFC domain
 IPR001846  von Willebrand factor, type D domain
 IPR002919  Trypsin Inhibitor-like, cysteine rich domain
 IPR006207  Cystine knot, C-terminal
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR025155  WxxW domain
 IPR036084  Serine protease inhibitor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0016266 O-glycan processing TAS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070701 mucus layer IDA
 molecular_functionGO:0005201 extracellular matrix structural constituent TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Dectin-2 family
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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