ENSMUSG00000037974


Mus musculus

Features
Gene ID: ENSMUSG00000037974
  
Biological name :Muc5ac
  
Synonyms : Muc5ac
  
Possible biological names infered from orthology : mucin 5AC, oligomeric mucus/gel-forming / P98088
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F5
Gene start: 141788972
Gene end: 141819231
  
Corresponding Affymetrix probe sets: 10559043 (MoGene1.0st)   1430899_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039699
Ensembl peptide - ENSMUSP00000131681
Ensembl peptide - ENSMUSP00000122353
NCBI entrez gene - 17833     See in Manteia.
MGI - MGI:104697
RefSeq - NM_010844
RefSeq - XM_006508499
RefSeq - XM_006508500
RefSeq Peptide - NP_034974
swissprot - E9PWB6
swissprot - E9QAQ8
Ensembl - ENSMUSG00000037974
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 muc5.1ENSDARG00000070331Danio rerio
 muc5.2ENSDARG00000058556Danio rerio
 muc5.3ENSDARG00000099470Danio rerio
 ENSGALG00000031737Gallus gallus
 ENSGALG00000034144Gallus gallus
 ovomucin precursor ENSGALG00000006717Gallus gallus
 MUC5ACENSG00000215182Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Muc5b / Q9HC84* / mucin 5B, oligomeric mucus/gel-forming*ENSMUSG0000006610846
Vwf / Von Willebrand factor / P04275*ENSMUSG0000000193024
Sspo / Q8CG65 / SCO-spondin ENSMUSG0000002979724
Otog / otogelin / Q6ZRI0*ENSMUSG0000000948722
Muc6 / mucin-6 / Q6W4X9* / mucin 6, oligomeric mucus/gel-forming*ENSMUSG0000004819121
Otogl / F7A4A7 / Otogelin-like protein / Q3ZCN5* / otogelin like*ENSMUSG0000009145520
Zan / zonadhesin / zonadhesin (gene/pseudogene)*ENSMUSG0000007917317
Fcgbp / Fc fragment of IgG binding protein*ENSMUSG0000004773016
9530053A07Rik / RIKEN cDNA 9530053A07 gene / FCGBP* / Fc fragment of IgG binding protein*ENSMUSG0000007877615
Tecta / O08523 / tectorin alpha / O75443*ENSMUSG0000003770513


Protein motifs (from Interpro)
Interpro ID Name
 IPR001007  VWFC domain
 IPR001846  von Willebrand factor, type D domain
 IPR002919  Trypsin Inhibitor-like, cysteine rich domain
 IPR006207  Cystine knot, C-terminal
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR025155  WxxW domain
 IPR036084  Serine protease inhibitor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0036438 maintenance of lens transparency IMP
 biological_processGO:0048015 phosphatidylinositol-mediated signaling ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0070701 mucus layer ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0012164 abnormal conjunctiva goblet cell morphology "any structural anomaly of a goblet cell that is part of the epithelium of the conjunctiva, and is the source of tear mucins which are secreted from it" [MGI:csmith]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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