ENSMUSG00000009487


Mus musculus

Features
Gene ID: ENSMUSG00000009487
  
Biological name :Otog
  
Synonyms : Otog / otogelin
  
Possible biological names infered from orthology : Q6ZRI0
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 46240987
Gene end: 46311434
  
Corresponding Affymetrix probe sets: 10553199 (MoGene1.0st)   1420797_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130949
Ensembl peptide - ENSMUSP00000147899
NCBI entrez gene - 18419     See in Manteia.
MGI - MGI:1202064
RefSeq - XM_017322025
RefSeq - NM_013624
RefSeq Peptide - NP_038652
swissprot - A0A1B0GSE0
swissprot - G3UWC8
Ensembl - ENSMUSG00000009487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otogENSDARG00000068460Danio rerio
 OTOGENSGALG00000006208Gallus gallus
 OTOGENSG00000188162Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otogl / F7A4A7 / Otogelin-like protein / Q3ZCN5* / otogelin like*ENSMUSG0000009145532
Vwf / Von Willebrand factor / P04275*ENSMUSG0000000193022
Muc5b / Q9HC84* / mucin 5B, oligomeric mucus/gel-forming*ENSMUSG0000006610821
Muc5ac / P98088* / mucin 5AC, oligomeric mucus/gel-forming*ENSMUSG0000003797421
Sspo / Q8CG65 / SCO-spondin ENSMUSG0000002979720
Muc6 / mucin-6 / Q6W4X9* / mucin 6, oligomeric mucus/gel-forming*ENSMUSG0000004819115
Zan / zonadhesin / zonadhesin (gene/pseudogene)*ENSMUSG0000007917315
Fcgbp / Fc fragment of IgG binding protein*ENSMUSG0000004773014
9530053A07Rik / RIKEN cDNA 9530053A07 gene / FCGBP* / Fc fragment of IgG binding protein*ENSMUSG0000007877613
Tecta / O08523 / tectorin alpha / O75443*ENSMUSG0000003770513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001007  VWFC domain
 IPR001846  von Willebrand factor, type D domain
 IPR002919  Trypsin Inhibitor-like, cysteine rich domain
 IPR006207  Cystine knot, C-terminal
 IPR007934  Alpha-L-arabinofuranosidase B, arabinose-binding domain
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR029034  Cystine-knot cytokine
 IPR030105  Otogelin
 IPR036084  Serine protease inhibitor-like superfamily
 IPR036195  Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0046373 L-arabinose metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046556 alpha-L-arabinofuranosidase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

Allelic Composition: Otogtwt-2J/Otogtwt-2J
Genetic Background: C57BR/cdJ-Otogtwt-2J/Kjn

Allelic Composition: Otogtwt-3J/Otogtwt-3J
Genetic Background: B6.D2-Otogtwt-3J/Kjn

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: PrkdcTg(INS-PDE2)5-1Lmb/?
Genetic Background: involves: FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: PrkdcTg(INS-PDE2)5-1Lmb/?
Genetic Background: involves: FVB/N

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
Show

Allelic Composition: PrkdcTg(INS-PDE2)5-1Lmb/?
Genetic Background: involves: FVB/N

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt-2J/Otogtwt-2J
Genetic Background: C57BR/cdJ-Otogtwt-2J/Kjn

Allelic Composition: Otogtwt-3J/Otogtwt-3J
Genetic Background: B6.D2-Otogtwt-3J/Kjn

Allelic Composition: Otogtwt-4J/Otogtwt-4J
Genetic Background: C57BL/6J-Otogtwt-4J/Kjn

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
Show

Allelic Composition: PrkdcTg(INS-PDE2)5-1Lmb/?
Genetic Background: involves: FVB/N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Otogtwt-2J/Otogtwt-2J
Genetic Background: C57BR/cdJ-Otogtwt-2J/Kjn

Allelic Composition: Otogtwt-3J/Otogtwt-3J
Genetic Background: B6.D2-Otogtwt-3J/Kjn

Allelic Composition: Otogtwt-4J/Otogtwt-4J
Genetic Background: C57BL/6J-Otogtwt-4J/Kjn

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002894 abnormal otoliths "malformed crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otogtwt-2J/Otogtwt-2J
Genetic Background: C57BR/cdJ-Otogtwt-2J/Kjn

Allelic Composition: Otogtwt-3J/Otogtwt-3J
Genetic Background: B6.D2-Otogtwt-3J/Kjn

Allelic Composition: Otogtwt-4J/Otogtwt-4J
Genetic Background: C57BL/6J-Otogtwt-4J/Kjn

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

 MP:0002895 abnormal otolithic membrane "malformations of the gelatinous membrane surmounting the acoustic maculae of the saccule and utricle and containing minute calciferous particles (otoliths)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

 MP:0003145 detached otolithic membrane "the otolithic (otoconial) membrane is abnormally detached from the underlying neuroepithelium" [J:60193, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
Show

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004330 abnormal saccular macula morphology "any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004517 decreased vestibular hair cell stereocilia number "decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

Allelic Composition: Otogtwt-2J/Otogtwt-2J
Genetic Background: C57BR/cdJ-Otogtwt-2J/Kjn

Allelic Composition: Otogtwt-3J/Otogtwt-3J
Genetic Background: B6.D2-Otogtwt-3J/Kjn

Allelic Composition: Otogtwt-4J/Otogtwt-4J
Genetic Background: C57BL/6J-Otogtwt-4J/Kjn

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

 MP:0006328 nonsyndromic hearing impairment "a form of hearing impairment that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otogvbd/Otogvbd
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Otogtwt/Otogtwt
Genetic Background: involves: C3HeB/Fe * C57BL/6

Allelic Composition: Otogtwt-2J/Otogtwt-2J
Genetic Background: C57BR/cdJ-Otogtwt-2J/Kjn

Allelic Composition: Otogtwt-3J/Otogtwt-3J
Genetic Background: B6.D2-Otogtwt-3J/Kjn

Allelic Composition: Otogtwt-4J/Otogtwt-4J
Genetic Background: C57BL/6J-Otogtwt-4J/Kjn

Allelic Composition: Otogtwt-5J/Otogtwt-5J
Genetic Background: C57BL/6J-Otogtwt-5J/Kjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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