ENSMUSG00000037705


Mus musculus

Features
Gene ID: ENSMUSG00000037705
  
Biological name :Tecta
  
Synonyms : O08523 / Tecta / tectorin alpha
  
Possible biological names infered from orthology : O75443
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.1
Gene start: 42329619
Gene end: 42399929
  
Corresponding Affymetrix probe sets: 10592593 (MoGene1.0st)   1419632_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040262
Ensembl peptide - ENSMUSP00000125370
NCBI entrez gene - 21683     See in Manteia.
MGI - MGI:109575
RefSeq - XM_017313276
RefSeq - NM_001324548
RefSeq - NM_009347
RefSeq - XM_006510152
RefSeq Peptide - NP_001311477
RefSeq Peptide - NP_033373
swissprot - O08523
Ensembl - ENSMUSG00000037705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tectaENSDARG00000059558Danio rerio
 TECTAENSGALG00000040857Gallus gallus
 TECTAENSG00000109927Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcgbp / Fc fragment of IgG binding protein*ENSMUSG0000004773026
9530053A07Rik / RIKEN cDNA 9530053A07 gene / FCGBP* / Fc fragment of IgG binding protein*ENSMUSG0000007877625
Zan / zonadhesin / zonadhesin (gene/pseudogene)*ENSMUSG0000007917321
Sspo / Q8CG65 / SCO-spondin ENSMUSG0000002979718
Otog / otogelin / Q6ZRI0*ENSMUSG0000000948717
Vwf / Von Willebrand factor / P04275*ENSMUSG0000000193017
Otogl / F7A4A7 / Otogelin-like protein / Q3ZCN5* / otogelin like*ENSMUSG0000009145517
Muc5b / Q9HC84* / mucin 5B, oligomeric mucus/gel-forming*ENSMUSG0000006610817
Muc5ac / P98088* / mucin 5AC, oligomeric mucus/gel-forming*ENSMUSG0000003797417
Muc6 / mucin-6 / Q6W4X9* / mucin 6, oligomeric mucus/gel-forming*ENSMUSG0000004819113


Protein motifs (from Interpro)
Interpro ID Name
 IPR001007  VWFC domain
 IPR001507  Zona pellucida domain
 IPR001846  von Willebrand factor, type D domain
 IPR002919  Trypsin Inhibitor-like, cysteine rich domain
 IPR003886  NIDO domain
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR017977  Zona pellucida domain, conserved site
 IPR025615  TILa domain
 IPR033026  Alpha-tectorin
 IPR036084  Serine protease inhibitor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007605 sensory perception of sound TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabrdtm1.1Jmag/Gabrd+,Gad2tm2(cre)Zjh/Gad2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0001963 abnormal hearing "anomaly in the ability to receive auditory stimuli" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm2Gpr/Tecta+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002895 abnormal otolithic membrane "malformations of the gelatinous membrane surmounting the acoustic maculae of the saccule and utricle and containing minute calciferous particles (otoliths)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003143 enlarged otoliths "increased average size of the crystalline calciferous particles adhering to the otolithic membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003144 reduced number of otoliths "decreased average number of the crystalline calciferous particles adhering to the otolithic membrane" [J:30611, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm2Gpr/Tecta+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm3.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm3.1Gpr/Tectatm3.1Gpr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm4.1Gpr/Tectatm4.1Gpr
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tectatm5.1Gpr
Genetic Background: involves: 129S/SvEv

 MP:0003150 detached tectorial membrane "tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm2Gpr/Tectatm2Gpr
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

 MP:0004412 abnormal cochlear microphonics "anomalous bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; the cochlear microphonic (CM) is an electric response dominated by OHC receptor potentials from the basal turn of the cochlea and provides a measure of transducer function in OHCs; in an active ear, CM waveforms show post-stimulus ringing (i.e. a cochlear echo) whereas in a passive ear system, CM decays at the cessation of the tone burst" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

 MP:0004414 decreased cochlear microphonics "reduction of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004431 abnormal hair cell mechanoelectric transduction "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004434 abnormal cochlear outer hair cell physiology "anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tectatm3.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm3.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0006336 abnormal otoacoustic response "anomaly in the acoustic energy produced by the cochlea in the presence or absence of sound stimulation" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Slc26a5tm1Jnz/Slc26a5tm1Jnz,Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S7/SvEvBrd * CBA

Allelic Composition: Slc26a5tm1Jnz/Slc26a5tm1Jnz,Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S7/SvEvBrd * CBA

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm3.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0013961 abnormal Hensen stripe morphology "any structural anomaly of the dark, nonstriated, V-shaped band (ridge) found on the underside of the tectorial membrane (TM) in the basal region of the cochlea, from which fine gelatinous trabeculae extend to fix the TM to the border cells, i.e. cells directly adjacent to the inner phalangeal cells; Hensen s stripe is continuous with a more external homogeneous basal layer, from which a marginal band of an amorphous substance originates; the marginal net extends from the marginal band and attaches the lateral border of the TM to Hensen s cells of the organ of Corti. Hensen s stripe and the homogeneous basal layers display interruptions through which the fibrillar structure of the TM is visible" [ISBN:3662026767, PMID:25080593]
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Allelic Composition: Tectatm3.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0013962 absent Hensen stripe "absence of the dark, nonstriated, V-shaped band (ridge) that is normally found on the underside of the tectorial membrane (TM) in the basal region of the cochlea, from which fine gelatinous trabeculae extend to fix the TM to the border cells, i.e. cells directly adjacent to the inner phalangeal cells" [ISBN:3662026767, PMID:25080593]
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Allelic Composition: Tectatm2Gpr/Tecta+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0014088 abnormal Kimura membrane morphology "any structural anomaly of the thickening of the lower surface of the tectorial membrane into which the hair bundles of the outer hair cells are imbedded" [PMID:18797289, PMID:24363064]
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Allelic Composition: Tectatm2Gpr/Tecta+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * CBA

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0014089 abnormal tectorial membrane marginal band morphology "any structural anomaly of the dense thickening of the lateral edge of the tectorial membrane" [PMID:18797289, PMID:24363064]
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Allelic Composition: Tectatm2Gpr/Tecta+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tectatm3.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0014090 abnormal tectorial membrane covernet morphology "any structural anomaly of the anastomosing network of large caliber fibrils that run predominantly longitudinally over the upper surface of the tectorial membrane; in mice, the covernet fibrils are continuous with the underlying striated-sheet matrix of the TM, and appear as electron-dense rods that can be a micron or more in diameter" [PMID:18797289, PMID:24363064]
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Allelic Composition: Tectatm3.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

 MP:0014091 abnormal tectorial membrane striated-sheet matrix morphology "any structural anomaly of the laminated, striated-sheet matrix within which collagen fibrils of the TM are imbedded; the striated sheet matrix is formed by two types of fine-diameter collagen filaments, a light and a dark staining type that lie in parallel within the plane of each sheet and are extensively linked along their length by staggered cross bridges; it originates medially within the sulcal zone, extends to the marginal band and is particularly evident in apical regions of the cochlea, where it has a less compressed appearance" [PMID:18797289, PMID:24363064]
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Allelic Composition: Ring1tm1Mvi/Ring1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tectatm2Gpr/Tecta+
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tectatm4.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tectatm5.1Gpr/Tecta+
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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