ENSMUSG00000066108


Mus musculus

Features
Gene ID: ENSMUSG00000066108
  
Biological name :Muc5b
  
Synonyms : Muc5b
  
Possible biological names infered from orthology : mucin 5B, oligomeric mucus/gel-forming / Q9HC84
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F5
Gene start: 141839070
Gene end: 141873084
  
Corresponding Affymetrix probe sets: 10559095 (MoGene1.0st)   1427626_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128276
NCBI entrez gene - 74180     See in Manteia.
MGI - MGI:1921430
RefSeq - NM_028801
RefSeq - XM_006508653
RefSeq Peptide - NP_083077
swissprot - E9Q5I3
Ensembl - ENSMUSG00000066108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 muc5.1ENSDARG00000070331Danio rerio
 muc5.2ENSDARG00000058556Danio rerio
 muc5.3ENSDARG00000099470Danio rerio
 ENSGALG00000031737Gallus gallus
 ENSGALG00000034144Gallus gallus
 ovomucin precursor ENSGALG00000006717Gallus gallus
 MUC5BENSG00000117983Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Muc5ac / P98088* / mucin 5AC, oligomeric mucus/gel-forming*ENSMUSG0000003797426
Sspo / Q8CG65 / SCO-spondin ENSMUSG0000002979714
Vwf / Von Willebrand factor / P04275*ENSMUSG0000000193014
Muc6 / mucin-6 / Q6W4X9* / mucin 6, oligomeric mucus/gel-forming*ENSMUSG0000004819113
Otog / otogelin / Q6ZRI0*ENSMUSG0000000948713
Zan / zonadhesin / zonadhesin (gene/pseudogene)*ENSMUSG0000007917311
Otogl / F7A4A7 / Otogelin-like protein / Q3ZCN5* / otogelin like*ENSMUSG0000009145511
Fcgbp / Fc fragment of IgG binding protein*ENSMUSG000000477309
9530053A07Rik / RIKEN cDNA 9530053A07 gene / FCGBP* / Fc fragment of IgG binding protein*ENSMUSG000000787768
Tecta / O08523 / tectorin alpha / O75443*ENSMUSG000000377058


Protein motifs (from Interpro)
Interpro ID Name
 IPR001007  VWFC domain
 IPR001846  von Willebrand factor, type D domain
 IPR002919  Trypsin Inhibitor-like, cysteine rich domain
 IPR006207  Cystine knot, C-terminal
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR025155  WxxW domain
 IPR036084  Serine protease inhibitor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043030 regulation of macrophage activation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008691 decreased interleukin-23 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0010752 impaired mucociliary clearance "reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [MESH:E01.370.386.520, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0012549 hypoxemia "subnormal arterial oxygen tension; deficient oxygenation of arterial blood" [ISBN:978-0-387-75246-4]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0030410 middle ear effusion "fluid accumulation in the middle ear cavity due to dysfunction of the Eustachian tube" [https://www.medscape.org/viewarticle/730698, PMID:1267372]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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