ENSG00000186141


Homo sapiens

Features
Gene ID: ENSG00000186141
  
Biological name :POLR3C
  
Synonyms : POLR3C / Q9BUI4 / RNA polymerase III subunit C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.1
Gene start: 145824088
Gene end: 145842505
  
Corresponding Affymetrix probe sets: 209382_at (Human Genome U133 Plus 2.0 Array)   210573_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334564
Ensembl peptide - ENSP00000358300
NCBI entrez gene - 10623     See in Manteia.
OMIM - 617454
RefSeq - XM_005272928
RefSeq - NM_001303456
RefSeq - NM_006468
RefSeq - XM_005272927
RefSeq Peptide - NP_001290385
RefSeq Peptide - NP_006459
swissprot - E9PHH9
swissprot - Q9BUI4
swissprot - A0A024R4C1
Ensembl - ENSG00000186141
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polr3cENSDARG00000057562Danio rerio
 Polr3cENSMUSG00000028099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008806  RNA polymerase III Rpc82, C -terminal
 IPR013197  RNA polymerase III subunit RPC82-related, helix-turn-helix
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006359 regulation of transcription by RNA polymerase III TAS
 biological_processGO:0006383 transcription by RNA polymerase III IEA
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0032728 positive regulation of interferon-beta production IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005666 DNA-directed RNA polymerase III complex TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0001056 RNA polymerase III activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Chain Elongation
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113356 O15318 / POLR3G / RNA polymerase III subunit G  / complex
 ENSG00000132664 POLR3F / Q9H1D9 / RNA polymerase III subunit F  / complex
 ENSG00000121851 Q9BT43 / POLR3GL / RNA polymerase III subunit G like  / complex






 

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