ENSG00000186891


Homo sapiens

Features
Gene ID: ENSG00000186891
  
Biological name :TNFRSF18
  
Synonyms : Q9Y5U5 / TNF receptor superfamily member 18 / TNFRSF18
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.33
Gene start: 1203508
Gene end: 1206691
  
Corresponding Affymetrix probe sets: 223851_s_at (Human Genome U133 Plus 2.0 Array)   224553_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328207
Ensembl peptide - ENSP00000368567
Ensembl peptide - ENSP00000368570
Ensembl peptide - ENSP00000462735
NCBI entrez gene - 8784     See in Manteia.
OMIM - 603905
RefSeq - XM_017002722
RefSeq - NM_004195
RefSeq - NM_148901
RefSeq - NM_148902
RefSeq Peptide - NP_004186
RefSeq Peptide - NP_683699
RefSeq Peptide - NP_683700
swissprot - Q9Y5U5
swissprot - J3KT02
Ensembl - ENSG00000186891
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfrsf18ENSDARG00000076800Danio rerio
 TNFRSF18ENSGALG00000001882Gallus gallus
 O35714ENSMUSG00000041954Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR022318  Tumour necrosis factor receptor 18
 IPR034018  Tumour necrosis factor receptor 18, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002687 positive regulation of leukocyte migration IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045589 regulation of regulatory T cell differentiation TAS
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120337 Q9UNG2 / TNFSF18 / TNF superfamily member 18  / complex / reaction






 

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