ENSMUSG00000041954


Mus musculus

Features
Gene ID: ENSMUSG00000041954
  
Biological name :Tnfrsf18
  
Synonyms : O35714 / Tnfrsf18 / tumor necrosis factor receptor superfamily, member 18
  
Possible biological names infered from orthology : Q9Y5U5 / TNF receptor superfamily member 18
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 156026164
Gene end: 156028895
  
Corresponding Affymetrix probe sets: 10511290 (MoGene1.0st)   1422303_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040035
Ensembl peptide - ENSMUSP00000099462
Ensembl peptide - ENSMUSP00000113277
NCBI entrez gene - 21936     See in Manteia.
MGI - MGI:894675
RefSeq - XM_017320113
RefSeq - NM_009400
RefSeq - NM_021985
RefSeq Peptide - NP_033426
RefSeq Peptide - NP_068820
swissprot - O35714
swissprot - Q540M6
swissprot - B1ASL6
Ensembl - ENSMUSG00000041954
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfrsf18ENSDARG00000076800Danio rerio
 TNFRSF18ENSGALG00000001882Gallus gallus
 Q9Y5U5ENSG00000186891Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR022318  Tumour necrosis factor receptor 18
 IPR034018  Tumour necrosis factor receptor 18, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002687 positive regulation of leukocyte migration ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pkd2tm1Dwo/Pkd2tm1Dwo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Pkd2tm1Dwo/Pkd2tm1Dwo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pkd2tm1Dwo/Pkd2tm1Dwo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkd2tm1Dwo/Pkd2tm1Dwo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Pkd2tm1Dwo/Pkd2tm1Dwo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000066755 Q7TS55 / Tnfsf18 / Tumor necrosis factor ligand superfamily member 18 / Q9UNG2* / TNF superfamily member 18*  / complex / reaction






 

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