ENSMUSG00000066755


Mus musculus

Features
Gene ID: ENSMUSG00000066755
  
Biological name :Tnfsf18
  
Synonyms : Q7TS55 / Tnfsf18 / Tumor necrosis factor ligand superfamily member 18
  
Possible biological names infered from orthology : Q9UNG2 / TNF superfamily member 18
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.1
Gene start: 161494655
Gene end: 161505290
  
Corresponding Affymetrix probe sets: 10351099 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000083251
NCBI entrez gene - 240873     See in Manteia.
MGI - MGI:2673064
RefSeq - NM_183391
RefSeq Peptide - NP_899247
swissprot - Q7TS55
Ensembl - ENSMUSG00000066755
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9UNG2ENSG00000120337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002309 T cell proliferation involved in immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002687 positive regulation of leukocyte migration ISO
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0042129 regulation of T cell proliferation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IMP
 biological_processGO:0090073 positive regulation of protein homodimerization activity IMP
 biological_processGO:2000329 negative regulation of T-helper 17 cell lineage commitment IMP
 biological_processGO:2000508 regulation of dendritic cell chemotaxis IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IDA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041954 O35714 / Tnfrsf18 / tumor necrosis factor receptor superfamily, member 18 / Q9Y5U5* / TNF receptor superfamily member 18*  / complex / reaction






 

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