ENSG00000188488


Homo sapiens

Features
Gene ID: ENSG00000188488
  
Biological name :SERPINA5
  
Synonyms : P05154 / SERPINA5 / serpin family A member 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.13
Gene start: 94561442
Gene end: 94593120
  
Corresponding Affymetrix probe sets: 209443_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451650
Ensembl peptide - ENSP00000452469
Ensembl peptide - ENSP00000451697
Ensembl peptide - ENSP00000333203
Ensembl peptide - ENSP00000450484
Ensembl peptide - ENSP00000450485
Ensembl peptide - ENSP00000450745
Ensembl peptide - ENSP00000450837
Ensembl peptide - ENSP00000451126
Ensembl peptide - ENSP00000451215
Ensembl peptide - ENSP00000451487
Ensembl peptide - ENSP00000451610
NCBI entrez gene - 5104     See in Manteia.
OMIM - 601841
RefSeq - NM_000624
RefSeq Peptide - NP_000615
swissprot - G3V2M1
swissprot - G3V3F5
swissprot - G3V3Y3
swissprot - G3V482
swissprot - G3V4B4
swissprot - G3V5Q9
swissprot - A0A024R6N9
swissprot - P05154
swissprot - G3V264
swissprot - G3V265
Ensembl - ENSG00000188488
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpina1ENSDARG00000090286Danio rerio
 serpina1lENSDARG00000090850Danio rerio
 serpina7ENSDARG00000087143Danio rerio
 si:ch211-186e20.2ENSDARG00000074712Danio rerio
 si:ch211-186e20.7ENSDARG00000077960Danio rerio
 zgc:174259ENSDARG00000091136Danio rerio
 ENSGALG00000020388Gallus gallus
 ENSGALG00000028598Gallus gallus
 ENSGALG00000046409Gallus gallus
 ENSGALG00000020390Gallus gallus
 SPIA1ENSGALG00000023070Gallus gallus
 SPIA4ENSGALG00000010969Gallus gallus
 P70458ENSMUSG00000041550Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P01011 / SERPINA3 / serpin family A member 3ENSG0000019613646
Q86WD7 / SERPINA9 / serpin family A member 9ENSG0000017005445
P29622 / SERPINA4 / serpin family A member 4ENSG0000010066545
P01009 / SERPINA1 / serpin family A member 1ENSG0000019724943
P08185 / SERPINA6 / serpin family A member 6ENSG0000017009941
Q86U17 / SERPINA11 / serpin family A member 11ENSG0000018691040
P05543 / SERPINA7 / serpin family A member 7ENSG0000012356137
Q8IW75 / SERPINA12 / serpin family A member 12ENSG0000016595336
Q9UK55 / SERPINA10 / serpin family A member 10ENSG0000014009331
P05546 / SERPIND1 / serpin family D member 1ENSG0000009993729
SERPINA2 / serpin family A member 2 (gene/pseudogene)ENSG0000025859726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization NAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IMP
 biological_processGO:0061107 seminal vesicle development IEA
 cellular_componentGO:0002080 acrosomal membrane IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031091 platelet alpha granule IDA
 cellular_componentGO:0031094 platelet dense tubular network IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0036024 protein C inhibitor-TMPRSS7 complex IDA
 cellular_componentGO:0036025 protein C inhibitor-TMPRSS11E complex IDA
 cellular_componentGO:0036026 protein C inhibitor-PLAT complex IDA
 cellular_componentGO:0036027 protein C inhibitor-PLAU complex IDA
 cellular_componentGO:0036028 protein C inhibitor-thrombin complex IDA
 cellular_componentGO:0036029 protein C inhibitor-KLK3 complex IDA
 cellular_componentGO:0036030 protein C inhibitor-plasma kallikrein complex IDA
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0097181 protein C inhibitor-coagulation factor V complex IDA
 cellular_componentGO:0097182 protein C inhibitor-coagulation factor Xa complex IDA
 cellular_componentGO:0097183 protein C inhibitor-coagulation factor XI complex IDA
 molecular_functionGO:0001972 retinoic acid binding IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005539 glycosaminoglycan binding TAS
 molecular_functionGO:0008201 heparin binding TAS
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IDA
 molecular_functionGO:0032190 acrosin binding IPI


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115718 PROC / P04070 / protein C, inactivator of coagulation factors Va and VIIIa  / reaction / complex






 

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