ENSG00000196136


Homo sapiens

Features
Gene ID: ENSG00000196136
  
Biological name :SERPINA3
  
Synonyms : P01011 / SERPINA3 / serpin family A member 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.13
Gene start: 94612377
Gene end: 94624055
  
Corresponding Affymetrix probe sets: 202376_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451119
Ensembl peptide - ENSP00000452246
Ensembl peptide - ENSP00000481617
Ensembl peptide - ENSP00000452476
Ensembl peptide - ENSP00000376793
Ensembl peptide - ENSP00000376795
Ensembl peptide - ENSP00000450540
NCBI entrez gene - 12     See in Manteia.
OMIM - 107280
RefSeq - NM_001085
RefSeq Peptide - NP_001076
swissprot - G3V3A0
swissprot - A0A087WY93
swissprot - P01011
swissprot - G3V595
swissprot - A0A024R6P0
Ensembl - ENSG00000196136
  
Related genetic diseases (OMIM): 107280 - Alpha-1-antichymotrypsin deficiency
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpina1ENSDARG00000090286Danio rerio
 serpina1lENSDARG00000090850Danio rerio
 serpina7ENSDARG00000087143Danio rerio
 si:ch211-186e20.2ENSDARG00000074712Danio rerio
 si:ch211-186e20.7ENSDARG00000077960Danio rerio
 zgc:174259ENSDARG00000091136Danio rerio
 ENSGALG00000028598Gallus gallus
 ENSGALG00000020388Gallus gallus
 ENSGALG00000046409Gallus gallus
 ENSGALG00000020390Gallus gallus
 SPIA1ENSGALG00000023070Gallus gallus
 SPIA4ENSGALG00000010969Gallus gallus
 P29621ENSMUSG00000066361Mus musculus
 Q03734ENSMUSG00000079012Mus musculus
 Q6P4P1ENSMUSG00000041536Mus musculus
 Q80X76ENSMUSG00000066363Mus musculus
 Q8BYY9ENSMUSG00000066364Mus musculus
 Serpina3gENSMUSG00000041481Mus musculus
 Serpina3iENSMUSG00000079014Mus musculus
 Serpina3jENSMUSG00000079013Mus musculus
 Serpina3kENSMUSG00000058207Mus musculus
 Serpina3nENSMUSG00000021091Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86WD7 / SERPINA9 / serpin family A member 9ENSG0000017005444
P05154 / SERPINA5 / serpin family A member 5ENSG0000018848844
P08185 / SERPINA6 / serpin family A member 6ENSG0000017009944
P05543 / SERPINA7 / serpin family A member 7ENSG0000012356143
P01009 / SERPINA1 / serpin family A member 1ENSG0000019724943
P29622 / SERPINA4 / serpin family A member 4ENSG0000010066543
Q86U17 / SERPINA11 / serpin family A member 11ENSG0000018691041
Q8IW75 / SERPINA12 / serpin family A member 12ENSG0000016595334
P05546 / SERPIND1 / serpin family D member 1ENSG0000009993731
Q9UK55 / SERPINA10 / serpin family A member 10ENSG0000014009331
SERPINA2 / serpin family A member 2 (gene/pseudogene)ENSG0000025859727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0019216 regulation of lipid metabolic process NAS
 biological_processGO:0030277 maintenance of gastrointestinal epithelium NAS
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular NAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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