ENSG00000196547


Homo sapiens

Features
Gene ID: ENSG00000196547
  
Biological name :MAN2A2
  
Synonyms : MAN2A2 / mannosidase alpha class 2A member 2 / P49641
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q26.1
Gene start: 90902218
Gene end: 90922584
  
Corresponding Affymetrix probe sets: 202032_s_at (Human Genome U133 Plus 2.0 Array)   219999_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452948
Ensembl peptide - ENSP00000453078
Ensembl peptide - ENSP00000453140
Ensembl peptide - ENSP00000453253
Ensembl peptide - ENSP00000453341
Ensembl peptide - ENSP00000453659
Ensembl peptide - ENSP00000453740
Ensembl peptide - ENSP00000453956
Ensembl peptide - ENSP00000453999
Ensembl peptide - ENSP00000353655
Ensembl peptide - ENSP00000452631
Ensembl peptide - ENSP00000452691
Ensembl peptide - ENSP00000452813
Ensembl peptide - ENSP00000452866
Ensembl peptide - ENSP00000452897
Ensembl peptide - ENSP00000452928
NCBI entrez gene - 4122     See in Manteia.
OMIM - 600988
RefSeq - XM_005254910
RefSeq - NM_006122
RefSeq - XM_017022184
RefSeq - XM_017022185
RefSeq - NM_001320977
RefSeq - XM_011521565
RefSeq - XM_011521566
RefSeq Peptide - NP_006113
RefSeq Peptide - NP_001307906
swissprot - P49641
swissprot - A0A0C4DGL1
swissprot - H0YK77
swissprot - H0YKH9
swissprot - H0YKM7
swissprot - H0YKQ2
swissprot - H0YKT0
swissprot - H0YL67
swissprot - H0YLB9
swissprot - H0YLL4
swissprot - H0YLU3
swissprot - H0YML7
swissprot - H0YMU0
swissprot - H0YNC8
swissprot - H0YNG5
Ensembl - ENSG00000196547
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man2a2ENSDARG00000063101Danio rerio
 MAN2A2ENSGALG00000033790Gallus gallus
 Man2a2ENSMUSG00000038886Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAN2A1 / Q16706 / mannosidase alpha class 2A member 1ENSG0000011289354
MAN2B1 / O00754 / mannosidase alpha class 2B member 1ENSG0000010477424
MAN2B2 / Q9Y2E5 / mannosidase alpha class 2B member 2ENSG0000001328822
AC010422.5ENSG000002695906
AC010422.3ENSG000002692424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000602  Glycoside hydrolase family 38, N-terminal domain
 IPR011013  Galactose mutarotase-like domain superfamily
 IPR011330  Glycoside hydrolase/deacetylase, beta/alpha-barrel
 IPR011682  Glycosyl hydrolase family 38, C-terminal
 IPR015341  Glycoside hydrolase family 38, central domain
 IPR027291  Glycoside hydrolase 38, N-terminal domain superfamily
 IPR028995  Glycoside hydrolase families 57/38, central domain superfamily
 IPR037094  Glycoside hydrolase family 38, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006013 mannose metabolic process IBA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0006517 protein deglycosylation IBA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004559 alpha-mannosidase activity IBA
 molecular_functionGO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity TAS
 molecular_functionGO:0015923 mannosidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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