ENSMUSG00000038886


Mus musculus

Features
Gene ID: ENSMUSG00000038886
  
Biological name :Man2a2
  
Synonyms : Alpha-mannosidase 2x / Man2a2 / Q8BRK9
  
Possible biological names infered from orthology : mannosidase alpha class 2A member 2 / P49641
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 80349097
Gene end: 80371375
  
Corresponding Affymetrix probe sets: 10564909 (MoGene1.0st)   1435203_at (Mouse Genome 430 2.0 Array)   1457498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145688
Ensembl peptide - ENSMUSP00000146210
Ensembl peptide - ENSMUSP00000145916
Ensembl peptide - ENSMUSP00000145861
Ensembl peptide - ENSMUSP00000145820
Ensembl peptide - ENSMUSP00000095949
NCBI entrez gene - 140481     See in Manteia.
MGI - MGI:2150656
RefSeq - XM_006540599
RefSeq - NM_172903
RefSeq Peptide - NP_766491
swissprot - A0A0U1RPB8
swissprot - A0A0U1RQ19
swissprot - Q197W7
swissprot - Q3TSU5
swissprot - Q8BRK9
swissprot - A0A0U1RNS8
swissprot - A0A0U1RP42
Ensembl - ENSMUSG00000038886
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man2a2ENSDARG00000063101Danio rerio
 MAN2A2ENSGALG00000033790Gallus gallus
 MAN2A2ENSG00000196547Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Man2a1 / P27046 / Alpha-mannosidase 2 / Q16706* / mannosidase alpha class 2A member 1*ENSMUSG0000002408553
O09159 / Man2b1 / Lysosomal alpha-mannosidase / O00754* / AC010422.3* / AC010422.5* / mannosidase alpha class 2B member 1*ENSMUSG0000000514224
Man2b2 / O54782 / Epididymis-specific alpha-mannosidase / Q9Y2E5* / mannosidase alpha class 2B member 2*ENSMUSG0000002911922
Mrfap1 / Q9CQL7 / MORF4 family-associated protein 1 ENSMUSG000000553020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000602  Glycoside hydrolase family 38, N-terminal domain
 IPR011013  Galactose mutarotase-like domain superfamily
 IPR011330  Glycoside hydrolase/deacetylase, beta/alpha-barrel
 IPR011682  Glycosyl hydrolase family 38, C-terminal
 IPR015341  Glycoside hydrolase family 38, central domain
 IPR027291  Glycoside hydrolase 38, N-terminal domain superfamily
 IPR028995  Glycoside hydrolase families 57/38, central domain superfamily
 IPR037094  Glycoside hydrolase family 38, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006013 mannose metabolic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0006517 protein deglycosylation IBA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004559 alpha-mannosidase activity IEA
 molecular_functionGO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA
 molecular_functionGO:0015923 mannosidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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