ENSMUSG00000024085


Mus musculus

Features
Gene ID: ENSMUSG00000024085
  
Biological name :Man2a1
  
Synonyms : Alpha-mannosidase 2 / Man2a1 / P27046
  
Possible biological names infered from orthology : mannosidase alpha class 2A member 1 / Q16706
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.1
Gene start: 64600736
Gene end: 64755110
  
Corresponding Affymetrix probe sets: 10446376 (MoGene1.0st)   1448647_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083928
Ensembl peptide - ENSMUSP00000130529
NCBI entrez gene - 17158     See in Manteia.
MGI - MGI:104669
RefSeq - NM_008549
RefSeq - XM_006523739
RefSeq Peptide - NP_032575
swissprot - F6QMB7
swissprot - P27046
Ensembl - ENSMUSG00000024085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man2a1ENSDARG00000102200Danio rerio
 MAN2A1ENSGALG00000000255Gallus gallus
 MAN2A1ENSG00000112893Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Man2a2 / Q8BRK9 / Alpha-mannosidase 2x / P49641* / mannosidase alpha class 2A member 2*ENSMUSG0000003888653
Man2b2 / O54782 / Epididymis-specific alpha-mannosidase / Q9Y2E5* / mannosidase alpha class 2B member 2*ENSMUSG0000002911921
O09159 / Man2b1 / Lysosomal alpha-mannosidase / O00754* / AC010422.3* / AC010422.5* / mannosidase alpha class 2B member 1*ENSMUSG0000000514221
Mrfap1 / Q9CQL7 / MORF4 family-associated protein 1 ENSMUSG000000553020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000602  Glycoside hydrolase family 38, N-terminal domain
 IPR011013  Galactose mutarotase-like domain superfamily
 IPR011330  Glycoside hydrolase/deacetylase, beta/alpha-barrel
 IPR011682  Glycosyl hydrolase family 38, C-terminal
 IPR015341  Glycoside hydrolase family 38, central domain
 IPR027291  Glycoside hydrolase 38, N-terminal domain superfamily
 IPR028995  Glycoside hydrolase families 57/38, central domain superfamily
 IPR037094  Glycoside hydrolase family 38, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001889 liver development IGI
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006013 mannose metabolic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing IGI
 biological_processGO:0006517 protein deglycosylation IBA
 biological_processGO:0007005 mitochondrion organization IGI
 biological_processGO:0007033 vacuole organization IGI
 biological_processGO:0007585 respiratory gaseous exchange IGI
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0048286 lung alveolus development IGI
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005797 Golgi medial cisterna IEA
 cellular_componentGO:0005801 cis-Golgi network IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004559 alpha-mannosidase activity IEA
 molecular_functionGO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA
 molecular_functionGO:0015923 mannosidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IDA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
Show

Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005005 abnormal self tolerance "a defect in the normal lack of response to autologous (self) antigens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011370 increased mesangial cell apoptosis "increase in the number of phagocytic cells in the capillary tuft of the renal glomerulus undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Man2a1tm1Jxm/Man2a1tm1Jxm,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129-Rag1tm1Mom Man2a1tm1Jxm

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr