ENSMUSG00000005142


Mus musculus

Features
Gene ID: ENSMUSG00000005142
  
Biological name :Man2b1
  
Synonyms : Lysosomal alpha-mannosidase / Man2b1 / O09159
  
Possible biological names infered from orthology : AC010422.3 / AC010422.5 / mannosidase alpha class 2B member 1 / O00754
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 85083270
Gene end: 85098282
  
Corresponding Affymetrix probe sets: 10573583 (MoGene1.0st)   1416340_a_at (Mouse Genome 430 2.0 Array)   1436781_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147350
Ensembl peptide - ENSMUSP00000147441
Ensembl peptide - ENSMUSP00000034121
NCBI entrez gene - 17159     See in Manteia.
MGI - MGI:107286
RefSeq - XM_006530747
RefSeq - XM_006530748
RefSeq - XM_006530749
RefSeq - NM_010764
RefSeq Peptide - NP_034894
swissprot - O09159
swissprot - A0A1B0GR27
swissprot - A0A1B0GRA4
Ensembl - ENSMUSG00000005142
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man2b1ENSDARG00000001897Danio rerio
 AC010422.3ENSG00000269242Homo sapiens
 AC010422.5ENSG00000269590Homo sapiens
 MAN2B1ENSG00000104774Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Man2a2 / Q8BRK9 / Alpha-mannosidase 2x / P49641* / mannosidase alpha class 2A member 2*ENSMUSG0000003888628
Man2b2 / O54782 / Epididymis-specific alpha-mannosidase / Q9Y2E5* / mannosidase alpha class 2B member 2*ENSMUSG0000002911926
Man2a1 / P27046 / Alpha-mannosidase 2 / Q16706* / mannosidase alpha class 2A member 1*ENSMUSG0000002408524
Mrfap1 / Q9CQL7 / MORF4 family-associated protein 1 ENSMUSG000000553021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000602  Glycoside hydrolase family 38, N-terminal domain
 IPR011013  Galactose mutarotase-like domain superfamily
 IPR011330  Glycoside hydrolase/deacetylase, beta/alpha-barrel
 IPR011682  Glycosyl hydrolase family 38, C-terminal
 IPR015341  Glycoside hydrolase family 38, central domain
 IPR027291  Glycoside hydrolase 38, N-terminal domain superfamily
 IPR028995  Glycoside hydrolase families 57/38, central domain superfamily
 IPR037094  Glycoside hydrolase family 38, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006013 mannose metabolic process IMP
 biological_processGO:0006464 cellular protein modification process ISO
 biological_processGO:0006517 protein deglycosylation IBA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004559 alpha-mannosidase activity IMP
 molecular_functionGO:0005537 mannose binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Lysosomal oligosaccharide catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001460 abnormal olfactory -discrimination memory "defects in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003686 abnormal eye muscle morphology "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004081 abnormal globus pallidus morphology "malformation of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004292 abnormal spiral ligament fibrocyte morphology "any structural abnormality in the four types of fibrocytes (types I, II , III and IV) that constitute the spiral ligament" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005301 abnormal corneal endothelium morphology "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008265 abnormal hippocampus CA2 region morphology 
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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