ENSG00000198612


Homo sapiens

Features
Gene ID: ENSG00000198612
  
Biological name :COPS8
  
Synonyms : COP9 signalosome subunit 8 / COPS8 / Q99627
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 237085312
Gene end: 237100466
  
Corresponding Affymetrix probe sets: 202141_s_at (Human Genome U133 Plus 2.0 Array)   202142_at (Human Genome U133 Plus 2.0 Array)   202143_s_at (Human Genome U133 Plus 2.0 Array)   214260_at (Human Genome U133 Plus 2.0 Array)   236204_at (Human Genome U133 Plus 2.0 Array)   243152_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375865
Ensembl peptide - ENSP00000413696
Ensembl peptide - ENSP00000388655
Ensembl peptide - ENSP00000387212
Ensembl peptide - ENSP00000346340
NCBI entrez gene - 10920     See in Manteia.
OMIM - 616011
RefSeq - NM_006710
RefSeq - NM_198189
RefSeq Peptide - NP_006701
RefSeq Peptide - NP_937832
swissprot - Q99627
swissprot - A0A024R4D1
swissprot - F8WEF2
swissprot - H7C3S9
swissprot - E9PGT6
Ensembl - ENSG00000198612
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cops8ENSDARG00000024846Danio rerio
 COPS8ENSGALG00000033385Gallus gallus
 Cops8ENSMUSG00000034432Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033205  COP9 signalosome, subunit CSN8
 IPR033464  CSN8/PSMD8/EIF3K
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000338 protein deneddylation IEA
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010387 COP9 signalosome assembly IEA
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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