ENSMUSG00000034432


Mus musculus

Features
Gene ID: ENSMUSG00000034432
  
Biological name :Cops8
  
Synonyms : COP9 signalosome complex subunit 8 / Cops8 / Q8VBV7
  
Possible biological names infered from orthology : COP9 signalosome subunit 8 / Q99627
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 90602981
Gene end: 90613341
  
Corresponding Affymetrix probe sets: 10348456 (MoGene1.0st)   1415934_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140707
Ensembl peptide - ENSMUSP00000035884
Ensembl peptide - ENSMUSP00000139836
NCBI entrez gene - 108679     See in Manteia.
MGI - MGI:1915363
RefSeq - NM_133805
RefSeq - XM_006529064
RefSeq Peptide - NP_598566
swissprot - A0A087WPM5
swissprot - Q8VBV7
Ensembl - ENSMUSG00000034432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cops8ENSDARG00000024846Danio rerio
 COPS8ENSGALG00000033385Gallus gallus
 COPS8ENSG00000198612Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033205  COP9 signalosome, subunit CSN8
 IPR033464  CSN8/PSMD8/EIF3K
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000338 protein deneddylation ISO
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010387 COP9 signalosome assembly IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008180 COP9 signalosome ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004966 abnormal inner cell mass proliferation "any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Il1f5tm1Hblu/Il1f5+,Tg(KRT14-Il1f6)1Hblu/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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