ENSG00000213066


Homo sapiens

Features
Gene ID: ENSG00000213066
  
Biological name :FGFR1OP
  
Synonyms : FGFR1 oncogene partner / FGFR1OP / O95684
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q27
Gene start: 166999182
Gene end: 167094789
  
Corresponding Affymetrix probe sets: 1568678_s_at (Human Genome U133 Plus 2.0 Array)   205587_at (Human Genome U133 Plus 2.0 Array)   205588_s_at (Human Genome U133 Plus 2.0 Array)   214124_x_at (Human Genome U133 Plus 2.0 Array)   239434_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479115
Ensembl peptide - ENSP00000230248
Ensembl peptide - ENSP00000355812
NCBI entrez gene - 11116     See in Manteia.
OMIM - 605392
RefSeq - NM_001278690
RefSeq - NM_007045
RefSeq - NM_194429
RefSeq Peptide - NP_001265619
RefSeq Peptide - NP_008976
RefSeq Peptide - NP_919410
swissprot - O95684
swissprot - A0A087WV25
Ensembl - ENSG00000213066
  
Related genetic diseases (OMIM): 605392 - Myeloproliferative disorder
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgfr1opENSDARG00000003058Danio rerio
 FGFR1OPENSGALG00000011423Gallus gallus
 Q66JX5ENSMUSG00000069135Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006594  LIS1 homology motif
 IPR018993  FGFR1 oncogene partner (FOP), N-terminal dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0034453 microtubule anchoring IEA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030292 protein tyrosine kinase inhibitor activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Signaling by cytosolic FGFR1 fusion mutants
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Signaling by FGFR1 in disease
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction
 ENSG00000213066 O95684 / FGFR1OP / FGFR1 oncogene partner  / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / reaction






 

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