ENSGALG00000004246


Gallus gallus

Features
Gene ID: ENSGALG00000004246
  
Biological name :SLC6A4
  
Synonyms : SLC6A4 / sodium-dependent serotonin transporter
  
Possible biological names infered from orthology : P31645 / Q60857 / solute carrier family 6 member 4
  
Species: Gallus gallus
  
Chr. number: 19
Strand: -1
Band:
Gene start: 6202079
Gene end: 6214207
  
Corresponding Affymetrix probe sets: Gga.10763.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006742
NCBI entrez gene - 404747     See in Manteia.
RefSeq - NM_213572
RefSeq - XM_015295699
RefSeq - XM_015295700
RefSeq Peptide - NP_998737
swissprot - F1NZ44
Ensembl - ENSGALG00000004246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a4aENSDARG00000061165Danio rerio
 P31645ENSG00000108576Homo sapiens
 Q60857ENSMUSG00000020838Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLC6A2 / solute carrier family 6 member 2 / O55192* / P23975* / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2*ENSGALG0000000356045
P48029* / Q8VBW1* / SLC6A8* / solute carrier family 6 member 8* / solute carrier family 6 (neurotransmitter transporter, creatine), member 8*ENSGALG0000004141938
SLC6A14 / solute carrier family 6 member 14 / Q9JMA9* / Q9UN76* / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) *ENSGALG0000000595737
SLC6A11 / solute carrier family 6 member 11 / P31650* / P48066* / Sodium- and chloride-dependent GABA transporter 3 *ENSGALG0000000487937
SLC6A6 / solute carrier family 6 member 6 / O35316* / P31641* / solute carrier family 6 (neurotransmitter transporter, taurine), member 6*ENSGALG0000000642537
SLC6A7 / solute carrier family 6 member 7 / Q6PGE7* / Q99884* / Sodium-dependent proline transporter *ENSGALG0000000567237
SLC6A13 / solute carrier family 6 member 13 / P31649* / Q9NSD5* / Sodium- and chloride-dependent GABA transporter 2 *ENSGALG0000001298537
SLC6A12 / solute carrier family 6 member 12 / P48065* / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12*ENSGALG0000001929037
ENSGALG0000002798236
SLC6A5 / solute carrier family 6 member 5 / Q9Y345* / solute carrier family 6 (neurotransmitter transporter, glycine), member 5*ENSGALG0000000390836
SLC6A1 / solute carrier family 6 member 1 / P30531* / P31648* / Sodium- and chloride-dependent GABA transporter 1 *ENSGALG0000000492135
SLC6A9 / sodium- and chloride-dependent glycine transporter 1 / P28571* / P48067* / solute carrier family 6 member 9*ENSGALG0000001009835
ENSGALG0000001929135


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR013086  Sodium:neurotransmitter symporter, serotonin, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006837 serotonin transport IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0015844 monoamine transport IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0046621 negative regulation of organ growth IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IBA
 biological_processGO:0051610 serotonin uptake IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0090067 regulation of thalamus size IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0005330 dopamine:sodium symporter activity IBA
 molecular_functionGO:0005335 serotonin:sodium symporter activity IEA
 molecular_functionGO:0008504 monoamine transmembrane transporter activity IEA
 molecular_functionGO:0015222 serotonin transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
Serotonin clearance from the synaptic cleft


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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