ENSG00000108576


Homo sapiens

Features
Gene ID: ENSG00000108576
  
Biological name :SLC6A4
  
Synonyms : P31645 / SLC6A4 / solute carrier family 6 member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q11.2
Gene start: 30194319
Gene end: 30236002
  
Corresponding Affymetrix probe sets: 207519_at (Human Genome U133 Plus 2.0 Array)   241811_x_at (Human Genome U133 Plus 2.0 Array)   242009_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463172
Ensembl peptide - ENSP00000261707
Ensembl peptide - ENSP00000378298
Ensembl peptide - ENSP00000385822
NCBI entrez gene - 6532     See in Manteia.
OMIM - 182138
RefSeq - NM_001045
RefSeq Peptide - NP_001036
swissprot - J3KPR9
swissprot - J3QKP3
swissprot - P31645
Ensembl - ENSG00000108576
  
Related genetic diseases (OMIM): 164230 - {Obsessive-compulsive disorder}, 164230
  607834 - {Anxiety-related personality traits}, 607834
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a4aENSDARG00000061165Danio rerio
 SLC6A4ENSGALG00000004246Gallus gallus
 Q60857ENSMUSG00000020838Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P23975 / SLC6A2 / solute carrier family 6 member 2ENSG0000010354647
Q01959 / SLC6A3 / solute carrier family 6 member 3ENSG0000014231947
Q9Y345 / SLC6A5 / solute carrier family 6 member 5ENSG0000016597040
Q9NSD5 / SLC6A13 / solute carrier family 6 member 13ENSG0000001037940
P31641 / SLC6A6 / solute carrier family 6 member 6ENSG0000013138939
P48029 / SLC6A8 / solute carrier family 6 member 8ENSG0000013082139
P48065 / SLC6A12 / solute carrier family 6 member 12ENSG0000011118139
P48066 / SLC6A11 / solute carrier family 6 member 11ENSG0000013216439
Q99884 / SLC6A7 / solute carrier family 6 member 7ENSG0000001108339
Q9UN76 / SLC6A14 / solute carrier family 6 member 14ENSG0000026810438
P30531 / SLC6A1 / solute carrier family 6 member 1ENSG0000015710338
P48067 / SLC6A9 / solute carrier family 6 member 9ENSG0000019651737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR013086  Sodium:neurotransmitter symporter, serotonin, N-terminal
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006837 serotonin transport IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014064 positive regulation of serotonin secretion IEA
 biological_processGO:0015844 monoamine transport IDA
 biological_processGO:0021941 negative regulation of cerebellar granule cell precursor proliferation IEA
 biological_processGO:0032227 negative regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0042136 neurotransmitter biosynthetic process TAS
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0046621 negative regulation of organ growth IEA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IBA
 biological_processGO:0051610 serotonin uptake IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071321 cellular response to cGMP IEA
 biological_processGO:0090067 regulation of thalamus size IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0005330 dopamine:sodium symporter activity IBA
 molecular_functionGO:0005335 serotonin:sodium symporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008504 monoamine transmembrane transporter activity IDA
 molecular_functionGO:0015222 serotonin transmembrane transporter activity IMP
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0019811 cocaine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Serotonin clearance from the synaptic cleft


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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