ENSG00000268104


Homo sapiens

Features
Gene ID: ENSG00000268104
  
Biological name :SLC6A14
  
Synonyms : Q9UN76 / SLC6A14 / solute carrier family 6 member 14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q23
Gene start: 116436622
Gene end: 116461458
  
Corresponding Affymetrix probe sets: 219795_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000470801
NCBI entrez gene - 11254     See in Manteia.
OMIM - 300444
RefSeq - NM_007231
RefSeq Peptide - NP_009162
swissprot - Q9UN76
Ensembl - ENSG00000268104
  
Related genetic diseases (OMIM): 300306 - {Obesity, susceptibility to, BMIQ11}, 300306
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a14ENSDARG00000029866Danio rerio
 SLC6A14ENSGALG00000005957Gallus gallus
 Q9JMA9ENSMUSG00000031089Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y345 / SLC6A5 / solute carrier family 6 member 5ENSG0000016597051
Q99884 / SLC6A7 / solute carrier family 6 member 7ENSG0000001108343
P48067 / SLC6A9 / solute carrier family 6 member 9ENSG0000019651742
Q01959 / SLC6A3 / solute carrier family 6 member 3ENSG0000014231939
P31641 / SLC6A6 / solute carrier family 6 member 6ENSG0000013138938
P30531 / SLC6A1 / solute carrier family 6 member 1ENSG0000015710338
P48029 / SLC6A8 / solute carrier family 6 member 8ENSG0000013082138
Q9NSD5 / SLC6A13 / solute carrier family 6 member 13ENSG0000001037938
P23975 / SLC6A2 / solute carrier family 6 member 2ENSG0000010354638
P48065 / SLC6A12 / solute carrier family 6 member 12ENSG0000011118138
P48066 / SLC6A11 / solute carrier family 6 member 11ENSG0000013216437
P31645 / SLC6A4 / solute carrier family 6 member 4ENSG0000010857637


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003333 amino acid transmembrane transport IEA
 biological_processGO:0006520 cellular amino acid metabolic process TAS
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006865 amino acid transport TAS
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005215 transporter activity IBA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0015171 amino acid transmembrane transporter activity TAS
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters
Variant SLC6A14 may confer susceptibility towards obesity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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