ENSMUSG00000031089


Mus musculus

Features
Gene ID: ENSMUSG00000031089
  
Biological name :Slc6a14
  
Synonyms : Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
  
Possible biological names infered from orthology : Q9UN76 / solute carrier family 6 member 14
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A2
Gene start: 21714896
Gene end: 21742355
  
Corresponding Affymetrix probe sets: 10599008 (MoGene1.0st)   1420503_at (Mouse Genome 430 2.0 Array)   1420504_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033414
NCBI entrez gene - 56774     See in Manteia.
MGI - MGI:1890216
RefSeq - NM_020049
RefSeq Peptide - NP_064433
swissprot - A1L359
swissprot - Q9JMA9
Ensembl - ENSMUSG00000031089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a14ENSDARG00000029866Danio rerio
 SLC6A14ENSGALG00000005957Gallus gallus
 Q9UN76ENSG00000268104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5 / Q9Y345* / solute carrier family 6 member 5*ENSMUSG0000003972851
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202644
P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1 / P48067* / solute carrier family 6 member 9*ENSMUSG0000002854242
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160939
O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / P31641* / solute carrier family 6 member 6*ENSMUSG0000003009639
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536839
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010839
P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3 / P48066* / solute carrier family 6 member 11*ENSMUSG0000003030738
Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8 / P48029* / solute carrier family 6 member 8*ENSMUSG0000001955838
P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1 / P30531* / solute carrier family 6 member 1*ENSMUSG0000003031038
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010938
Q60857 / Slc6a4 / Sodium-dependent serotonin transporter / P31645* / solute carrier family 6 member 4*ENSMUSG0000002083837


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process IBA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0009636 response to toxic substance ISO
 biological_processGO:0015837 amine transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 molecular_functionGO:0005215 transporter activity IBA
 molecular_functionGO:0005275 amine transmembrane transporter activity ISS
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

Allelic Composition: Slc6a14tm1Gana/Slc6a14tm1Gana,Tg(MMTVneu)202Mul/0
Genetic Background: involves: FVB/N

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0008639 decreased circulating interleukin-1 alpha level "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

Allelic Composition: Slc6a14tm1Gana/Slc6a14tm1Gana,Tg(MMTVneu)202Mul/0
Genetic Background: involves: FVB/N

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd7tm1.1Dmm/Chd7tm1.1Dmm,Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a14tm1Gana/Slc6a14tm1Gana,Tg(MMTVneu)202Mul/0
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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