ENSMUSG00000019558


Mus musculus

Features
Gene ID: ENSMUSG00000019558
  
Biological name :Slc6a8
  
Synonyms : Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8
  
Possible biological names infered from orthology : P48029 / solute carrier family 6 member 8
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 73673150
Gene end: 73682502
  
Corresponding Affymetrix probe sets: 10600210 (MoGene1.0st)   1417116_at (Mouse Genome 430 2.0 Array)   1448596_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110111
Ensembl peptide - ENSMUSP00000132921
Ensembl peptide - ENSMUSP00000128079
Ensembl peptide - ENSMUSP00000126076
Ensembl peptide - ENSMUSP00000033752
Ensembl peptide - ENSMUSP00000110108
Ensembl peptide - ENSMUSP00000110109
NCBI entrez gene - 102857     See in Manteia.
MGI - MGI:2147834
RefSeq - NM_133987
RefSeq - NM_001142809
RefSeq - NM_001142810
RefSeq Peptide - NP_001136282
RefSeq Peptide - NP_001136281
RefSeq Peptide - NP_598748
swissprot - Q8VBW1
swissprot - E9Q151
swissprot - A2ALM6
swissprot - F6UKB4
swissprot - F7C668
swissprot - E9Q6T2
Ensembl - ENSMUSG00000019558
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a8ENSDARG00000043646Danio rerio
 ENSGALG00000041419Gallus gallus
 P48029ENSG00000130821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3 / P48066* / solute carrier family 6 member 11*ENSMUSG0000003030752
O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / P31641* / solute carrier family 6 member 6*ENSMUSG0000003009652
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010851
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010949
P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1 / P30531* / solute carrier family 6 member 1*ENSMUSG0000003031047
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202641
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536840
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160940
Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5 / Q9Y345* / solute carrier family 6 member 5*ENSMUSG0000003972840
P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1 / P48067* / solute carrier family 6 member 9*ENSMUSG0000002854239
Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) / Q9UN76* / solute carrier family 6 member 14*ENSMUSG0000003108938
Q60857 / Slc6a4 / Sodium-dependent serotonin transporter / P31645* / solute carrier family 6 member 4*ENSMUSG0000002083838


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR002984  Sodium:neurotransmitter symporter, creatine
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0015871 choline transport IEA
 biological_processGO:0015881 creatine transmembrane transport ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:1990403 embryonic brain development IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005308 creatine transmembrane transporter activity IEA
 molecular_functionGO:0005309 creatine:sodium symporter activity IBA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0015220 choline transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Creatine metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

Allelic Composition: Slc6a8tm1.1Lbar/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Prrt2tm1a(KOMP)Wtsi/Prrt2+
Genetic Background: C57BL/6N-Atm1Brd Prrt2tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

Allelic Composition: Slc6a8tm1.1Lbar/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

 MP:0002800 abnormal short-term recognition memory "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

Allelic Composition: Slc6a8tm1.1Lbar/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

Allelic Composition: Slc6a8tm1.1Lbar/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

Allelic Composition: Slc6a8tm1.1Lbar/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

Allelic Composition: Slc6a8tm1.1Lbar/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0010060 abnormal creatine concentration "anomaly in the amount per unit of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

 MP:0010061 increased creatine concentration "increase in the amount per unit of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

 MP:0010062 decreased creatine concentration "reduction in the amount per unit of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.1Clar/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

Allelic Composition: Slc6a8tm1.1Lbar/Y,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0010065 decreased circulating creatine level "reduction in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6N

 MP:0020083 decreased hippocampus volume "decrease from the average range of the hippocampus volume compared to normal" [GOC:NV]
Show

Allelic Composition: Slc6a8tm1.2Lbar/Y
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr