ENSMUSG00000039728


Mus musculus

Features
Gene ID: ENSMUSG00000039728
  
Biological name :Slc6a5
  
Synonyms : Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5
  
Possible biological names infered from orthology : Q9Y345 / solute carrier family 6 member 5
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B4
Gene start: 49910146
Gene end: 49963856
  
Corresponding Affymetrix probe sets: 10553430 (MoGene1.0st)   1425992_at (Mouse Genome 430 2.0 Array)   1442177_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146917
Ensembl peptide - ENSMUSP00000058699
Ensembl peptide - ENSMUSP00000103230
Ensembl peptide - ENSMUSP00000146430
NCBI entrez gene - 104245     See in Manteia.
MGI - MGI:105090
RefSeq - XM_006540549
RefSeq - XM_006540545
RefSeq - XM_006540546
RefSeq - XM_006540547
RefSeq - XM_006540548
RefSeq - NM_001146013
RefSeq - NM_148931
RefSeq Peptide - NP_683733
RefSeq Peptide - NP_001139485
swissprot - B2RQX9
swissprot - A0A140LHI9
Ensembl - ENSMUSG00000039728
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a5ENSDARG00000067964Danio rerio
 SLC6A5ENSGALG00000003908Gallus gallus
 Q9Y345ENSG00000165970Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) / Q9UN76* / solute carrier family 6 member 14*ENSMUSG0000003108941
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202639
P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1 / P48067* / solute carrier family 6 member 9*ENSMUSG0000002854239
P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1 / P30531* / solute carrier family 6 member 1*ENSMUSG0000003031034
P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3 / P48066* / solute carrier family 6 member 11*ENSMUSG0000003030733
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010833
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160933
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010933
O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / P31641* / solute carrier family 6 member 6*ENSMUSG0000003009632
Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8 / P48029* / solute carrier family 6 member 8*ENSMUSG0000001955832
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536832
Q60857 / Slc6a4 / Sodium-dependent serotonin transporter / P31645* / solute carrier family 6 member 4*ENSMUSG0000002083831


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0015816 glycine transport IEA
 biological_processGO:0060012 synaptic transmission, glycinergic IEA
 biological_processGO:1903804 glycine import across plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0015187 glycine transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015375 glycine:sodium symporter activity IEA


Pathways (from Reactome)
Pathway description
Na+/Cl- dependent neurotransmitter transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Polbtm1.1Jbsw/Polbtm1.1Jbsw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Polbtm1.1Jbsw/Polbtm1.1Jbsw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Polbtm1.1Jbsw/Polbtm1.1Jbsw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Slc6a5m1J/Slc6a5m1J
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a5m1J/Slc6a5m1J
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc6a5m1J/Slc6a5m1J
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Slc6a5m1J/Slc6a5m1J
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0005604 hyperekplexia "disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc6a5m1J/Slc6a5m1J
Genetic Background: involves: 129S2/SvPas * NOD

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Slc6a5m1J/Slc6a5m1J
Genetic Background: involves: 129S2/SvPas * NOD

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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