ENSMUSG00000030310


Mus musculus

Features
Gene ID: ENSMUSG00000030310
  
Biological name :Slc6a1
  
Synonyms : P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1
  
Possible biological names infered from orthology : P30531 / solute carrier family 6 member 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 114282635
Gene end: 114317532
  
Corresponding Affymetrix probe sets: 10540838 (MoGene1.0st)   1452142_at (Mouse Genome 430 2.0 Array)   1457183_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145080
Ensembl peptide - ENSMUSP00000032454
NCBI entrez gene - 232333     See in Manteia.
MGI - MGI:95627
RefSeq - NM_178703
RefSeq Peptide - NP_848818
swissprot - A0A0N4SVF5
swissprot - P31648
Ensembl - ENSMUSG00000030310
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a1aENSDARG00000045944Danio rerio
 slc6a1bENSDARG00000039647Danio rerio
 SLC6A1ENSGALG00000004921Gallus gallus
 P30531ENSG00000157103Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3 / P48066* / solute carrier family 6 member 11*ENSMUSG0000003030751
O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / P31641* / solute carrier family 6 member 6*ENSMUSG0000003009650
Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8 / P48029* / solute carrier family 6 member 8*ENSMUSG0000001955850
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010850
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010949
Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5 / Q9Y345* / solute carrier family 6 member 5*ENSMUSG0000003972845
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536844
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160943
P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1 / P48067* / solute carrier family 6 member 9*ENSMUSG0000002854242
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202642
Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) / Q9UN76* / solute carrier family 6 member 14*ENSMUSG0000003108941
Q60857 / Slc6a4 / Sodium-dependent serotonin transporter / P31645* / solute carrier family 6 member 4*ENSMUSG0000002083839


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR002980  Sodium:neurotransmitter symporter, GABA, GAT-1
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007612 learning IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009744 response to sucrose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0014054 positive regulation of gamma-aminobutyric acid secretion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014074 response to purine-containing compound IEA
 biological_processGO:0015812 gamma-aminobutyric acid transport IEA
 biological_processGO:0032229 negative regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051939 gamma-aminobutyric acid import IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0005332 gamma-aminobutyric acid:sodium symporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Na+/Cl- dependent neurotransmitter transporters
Reuptake of GABA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001987 alcohol preference 
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tnftm2.1Gkl/Tnftm2.1Gkl,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002629 hyperactivity elicited by ethanol administration 
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002635 reduced sensorimotor gating 
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002850 saccharin preference "subjects demonstrate desire for saccharine over other offered substance" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax6Mhdaaey18/Pax6+
Genetic Background: involves: C3HeB/FeJ

 MP:0003444 abnormal neurotransmitter uptake "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Mhdaaey18/Pax6+
Genetic Background: involves: C3HeB/FeJ

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0004210 abnormal bitter taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Slc6a1tm1Mlit/Slc6a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax6Mhdaaey18/Pax6+
Genetic Background: involves: C3HeB/FeJ

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a1tm1Mlit/Slc6a1tm1Mlit
Genetic Background: B6.129S1-Slc6a1tm1Mlit

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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