ENSMUSG00000030096


Mus musculus

Features
Gene ID: ENSMUSG00000030096
  
Biological name :Slc6a6
  
Synonyms : O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6
  
Possible biological names infered from orthology : P31641 / solute carrier family 6 member 6
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 91684053
Gene end: 91759066
  
Corresponding Affymetrix probe sets: 10540122 (MoGene1.0st)   1420148_at (Mouse Genome 430 2.0 Array)   1421346_a_at (Mouse Genome 430 2.0 Array)   1437149_at (Mouse Genome 430 2.0 Array)   1449751_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032185
Ensembl peptide - ENSMUSP00000146312
Ensembl peptide - ENSMUSP00000146306
Ensembl peptide - ENSMUSP00000145986
Ensembl peptide - ENSMUSP00000145794
NCBI entrez gene - 21366     See in Manteia.
MGI - MGI:98488
RefSeq - NM_009320
RefSeq - XM_011241279
RefSeq - XM_006505871
RefSeq - XM_006505870
RefSeq Peptide - NP_033346
swissprot - A0A0U1RQA5
swissprot - O35316
swissprot - Q3UPI8
swissprot - A0A0U1RP20
swissprot - A0A0U1RPH7
swissprot - A0A0U1RQA0
Ensembl - ENSMUSG00000030096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a6aENSDARG00000012534Danio rerio
 slc6a6bENSDARG00000098438Danio rerio
 SLC6A6ENSGALG00000006425Gallus gallus
 P31641ENSG00000131389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010860
P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3 / P48066* / solute carrier family 6 member 11*ENSMUSG0000003030759
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010957
Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8 / P48029* / solute carrier family 6 member 8*ENSMUSG0000001955853
P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1 / P30531* / solute carrier family 6 member 1*ENSMUSG0000003031048
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536842
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202641
Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5 / Q9Y345* / solute carrier family 6 member 5*ENSMUSG0000003972840
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160940
Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) / Q9UN76* / solute carrier family 6 member 14*ENSMUSG0000003108940
P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1 / P48067* / solute carrier family 6 member 9*ENSMUSG0000002854239
Q60857 / Slc6a4 / Sodium-dependent serotonin transporter / P31645* / solute carrier family 6 member 4*ENSMUSG0000002083839


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR002434  Sodium:neurotransmitter symporter, taurine
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0015734 taurine transport IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0005368 taurine transmembrane transporter activity IDA
 molecular_functionGO:0005369 taurine:sodium symporter activity IBA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edaraddcr/Edaraddcr
Genetic Background: involves: C57BL/6 * C3H

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Tlr3M2Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M2Btlr

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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