| MP:0000124 | absent teeth | "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi
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| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0000743 | muscle spasms | "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0000836 | abnormal substantia nigra morphology | "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0000897 | abnormal midbrain | "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: f/f+,KitW/Kit+
Genetic Background: FL/1Re-KitW/J
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0001386 | abnormal maternal nurturing | "failure of mothers to tend offspring" [J:39801] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0001392 | abnormal locomotor activity | "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Mlca4C57BL/6J/?,Slc6a3tm1Mca/Slc6a3+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Mlca5DBA/2J/?,Slc6a3tm1Mca/Slc6a3+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm1Wzh/Slc6a3tm1Wzh
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: B6.129X1-Slc6a3tm1Hhg
Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0001409 | increased stereotypic behavior | "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125] |
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0001415 | increased exploration in new environment | "greater amount of time spent investigating new location" [J:28825] |
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001417 | decreased exploration in new environment | "less amount of time spent investigating a new location" [J:79870] |
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0001440 | abnormal grooming behavior | "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv
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| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
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| MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001746 | abnormal pituitary secretion | "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0001906 | increased dopamine level | "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3tm3(tetO)Xz
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0002062 | abnormal conditioning behavior | "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac
Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Aplnrtm1Path/Aplnrtm1Path,Tg(Kdr-cre)#Brei/0
Genetic Background: involves: C57BL/6
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0002100 | abnormal tooth morphology | "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Slc6a3tm1(cre)Bkmn/Slc6a3tm1(cre)Bkmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL
Allelic Composition: Rpl22tm1.1Psam/Rpl22+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm1.1Asor/Slc6a3tm1.1Asor
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Mfn1tm1.1Arte/Mfn1tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0002184 | abnormal innervation | "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0002204 | abnormal neurotransmitter physiology | "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: B6.129X1-Slc6a3tm1Hhg
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0002272 | abnormal nervous system electrophysiology | "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ
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| MP:0002427 | dwarfism | "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0002573 | behavioral despair | "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395] |
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ
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| MP:0002574 | increased vertical activity | "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Slc6a3tm1Rbl/Slc6a3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0002797 | thigmotaxis | "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0002800 | abnormal short-term recognition memory | "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0002803 | abnormal operant conditional behavior | "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
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| MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0002910 | abnormal excitatory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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| MP:0002945 | abnormal inhibitory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: B6.129X1-Slc6a3tm1Hhg
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0003008 | enhanced long term potentiation | "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922] |
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Allelic Composition: Slc18a2tm1Mca/Slc18a2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0003172 | abnormal lysosome physiology | "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0003224 | neuron degeneration | "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0003243 | abnormal dopaminergic neuron morphology | "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0003244 | loss of dopaminergic neurons | "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Allelic Composition: Rettm1Kln/Rettm1Kln,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Slc6a3tm2(DTR)Rpa/Slc6a3+
Genetic Background: involves: C57BL/6
Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003348 | hypopituitarism | "reduction or cessation of secretion of one or more hormones from the anterior pituitary gland; this may result from ablation, tumors, infarction, or other trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0003444 | abnormal neurotransmitter uptake | "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0003461 | abnormal response to novel object | "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University] |
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003462 | abnormal response to novel odor | "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University] |
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Allelic Composition: Espnje/Espnje
Genetic Background: involves: 129X1/SvJ * JE/LeJ
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| MP:0003463 | abnormal single cell response | "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission] |
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
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| MP:0003633 | abnormal nervous system physiology | |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003638 | abnormal response/metabolism to endogenous compounds | "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0003964 | abnormal noradrenaline level | "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
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| MP:0003990 | decreased neurotransmitter release | "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004077 | abnormal striatum morphology | "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0004102 | abnormal dorsal striatum morphology | "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004143 | hypertonia | "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0004163 | abnormal adenophysis morphology | "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004191 | neuronal intranuclear inclusions | "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator] |
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Sncatm1Nbm/Sncatm1Nbm,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
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| MP:0004263 | abnormal limb posture | "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
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| MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0004753 | abnormal miniature excitatory postsynaptic currents | "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
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| MP:0004768 | abnormal axonal transport | "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0004792 | abnormal synaptic vesicle number | "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0004811 | abnormal neuron physiology | "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3tm3(tetO)Xz
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J
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| MP:0005058 | abnormal lysosome morphology | "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
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| MP:0005322 | abnormal serotonin level | "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0005361 | small pituitary gland | "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0005402 | abnormal action potential | "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3tm3(tetO)Xz
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kdm5bGt(RRO123)Byg/Kdm5bGt(RRO123)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005445 | abnormal neurotransmitter release | "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005603 | neuron hypertrophy | "increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005633 | increased circulating sodium level | "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Slc24a5tm1b(KOMP)Mbp/Slc24a5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Slc24a5tm1b(KOMP)Mbp/J
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| MP:0005643 | decreased dopamine level | "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Allelic Composition: Slc6a3tm1.1Jaja/Slc6a3tm1.1Jaja
Genetic Background: B6.129-Slc6a3tm1.1Jaja
Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Slc6a3tm2(DTR)Rpa/Slc6a3+
Genetic Background: involves: C57BL/6
Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0005646 | abnormal pituitary gland physiology | "anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn2tm3Dcc/Mfn2tm3Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J
Allelic Composition: Prkntm1Shn/Prkntm1Shn,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Pink1tm1Zhzh/Pink1tm1Zhzh,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0008143 | abnormal dendrite morphology | "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0008329 | decreased somatotroph cell number | "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0008332 | decreased lactotroph cell number | "reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0008365 | adenohypophysis hypoplasia | "underdevelopment or reduced size, usually due to a reduced cell number, of the anterior lobe of the pituitary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0008369 | pituitary intermediate lobe hypoplasia | "underdevelopment or reduced size, usually due to a reduced cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0008544 | impaired olfaction | "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0008571 | abnormal synaptic bouton morphology | "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750] |
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0008872 | abnormal response to xenobiotics | "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0008873 | increased sensitivity to xenobiotics | "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
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| MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0008911 | induced hyperactivity | "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
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| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0008947 | increased neuron number | "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0009435 | abnormal miniature inhibitory postsynaptic currents | "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: B6.129X1-Slc6a3tm1Hhg
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| MP:0009538 | abnormal synapse morphology | "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850] |
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Allelic Composition: Lmx1atm1Tpe/Lmx1atm1Tpe,Lmx1btm1Zfc/Lmx1btm1Zfc,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
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| MP:0009712 | impaired conditioned place preference behavior | "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Slc6a3tm1Hhg/Slc6a3tm1Hhg
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
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| MP:0009745 | abnormal behavioral response to xenobiotic | "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0009748 | abnormal behavioral response to addictive substance | "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm1Rpa/Grin1tm1.1Rpa,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
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| MP:0009752 | enhanced behavioral response to nicotine | "increased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
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| MP:0009754 | enhanced behavioral response to cocaine | "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
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| MP:0009756 | impaired behavioral response to nicotine | "decreased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
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| MP:0009758 | impaired behavioral response to cocaine | "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
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| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0010069 | increased serotonin concentration | "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0010149 | abnormal synaptic dopamine release | "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
Allelic Composition: Drd2tm1.1Mrub/Drd2tm1.1Mrub,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: B6.Cg-Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn
Allelic Composition: Rettm1Kln/Rettm1Kln,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Shhtm1Ahk/Shhtm1Ahk,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Oprk1tm2.1Kff/Oprk1tm2.1Kff,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6
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| MP:0010249 | lactation failure | "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
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| MP:0010831 | partial lethality | "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Slc6a3tm1Rbl/Slc6a3tm1Rbl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0010955 | abnormal respiratory electron transport chain | "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904] |
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Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011083 | complete lethality at weaning | "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith] |
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Allelic Composition: Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn,Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011448 | decreased dopaminergic neuron number | "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb] |
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Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ
Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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| MP:0011451 | increased susceptibility to dopaminergic neuron neurotoxicity | "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0011452 | decreased susceptibility to dopaminergic neuron neurotoxicity | "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sor+,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac,Slc6a3tm1.1(cre)Bkmn/Slc6a3+,Tg(CAG-Otx2,-GFP)21Asim/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Slc6a3tm1.1Jaja/Slc6a3tm1.1Jaja
Genetic Background: B6.129-Slc6a3tm1.1Jaja
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| MP:0011629 | decreased mitochondria number | "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011630 | increased mitochondria size | "enlarged the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0011631 | decreased mitochondria size | "reduced size of the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0011633 | abnormal mitochondrial shape | "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0011975 | neuronal cytoplasmic inclusions | "presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders" [MGI:mnk] |
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Allelic Composition: Slc6a3tm4.1(tTA)Xz/Slc6a3+,Tg(tetO-SNCA*A53T)E2Cai/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Prkntm1Shn/Prkntm1Shn,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Allelic Composition: Pink1tm1Zhzh/Pink1tm1Zhzh,Slc6a3tm4.1(tTA)Xz/?,Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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| MP:0013218 | abnormal substantia nigra pars reticulata morphology | "any structural anomaly of the anterior (ventral) part of grey matter of the substantia nigra which contains smaller and loosely packed cells than the pars compacta, only some of which contain a small amount of pigment; the cells of pars reticulata bear a strong structural and functional resemblance to the inner segment of the globus pallidus; many cells in this region use GABA as a neurotransmitter" [MGI:anna] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013219 | abnormal substantia nigra pars compacta morphology | "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Mfn2tm1.1Arte/Mfn2tm1.1Arte,Slc6a3tm1(cre)Lrsn/Slc6a3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0020448 | increased microglial cell activation | "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774] |
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn
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