ENSMUSG00000028542


Mus musculus

Features
Gene ID: ENSMUSG00000028542
  
Biological name :Slc6a9
  
Synonyms : P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1
  
Possible biological names infered from orthology : P48067 / solute carrier family 6 member 9
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.1
Gene start: 117834506
Gene end: 117875198
  
Corresponding Affymetrix probe sets: 10507500 (MoGene1.0st)   1417636_at (Mouse Genome 430 2.0 Array)   1431812_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118372
Ensembl peptide - ENSMUSP00000129359
Ensembl peptide - ENSMUSP00000127806
Ensembl peptide - ENSMUSP00000127289
Ensembl peptide - ENSMUSP00000127203
Ensembl peptide - ENSMUSP00000127093
Ensembl peptide - ENSMUSP00000122676
Ensembl peptide - ENSMUSP00000030269
Ensembl peptide - ENSMUSP00000066102
NCBI entrez gene - 14664     See in Manteia.
MGI - MGI:95760
RefSeq - NM_008135
RefSeq - XM_006502771
RefSeq Peptide - NP_032161
swissprot - E9Q036
swissprot - E9QA02
swissprot - P28571
swissprot - E9PWC4
swissprot - E9Q517
swissprot - E9Q3Z2
swissprot - E9Q3V0
Ensembl - ENSMUSG00000028542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a9ENSDARG00000018534Danio rerio
 SLC6A9ENSGALG00000010098Gallus gallus
 P48067ENSG00000196517Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202648
Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5 / Q9Y345* / solute carrier family 6 member 5*ENSMUSG0000003972848
Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) / Q9UN76* / solute carrier family 6 member 14*ENSMUSG0000003108942
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010840
P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1 / P30531* / solute carrier family 6 member 1*ENSMUSG0000003031040
Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8 / P48029* / solute carrier family 6 member 8*ENSMUSG0000001955840
P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3 / P48066* / solute carrier family 6 member 11*ENSMUSG0000003030739
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010938
O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / P31641* / solute carrier family 6 member 6*ENSMUSG0000003009638
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536838
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160937
Q60857 / Slc6a4 / Sodium-dependent serotonin transporter / P31645* / solute carrier family 6 member 4*ENSMUSG0000002083837


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR003028  Sodium:neurotransmitter symporter, glycine, type 1
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003333 amino acid transmembrane transport IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0015816 glycine transport IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061537 glycine secretion, neurotransmission IMP
 biological_processGO:1903825 organic acid transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005283 amino acid:sodium symporter activity IEA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0015187 glycine transmembrane transporter activity IDA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Na+/Cl- dependent neurotransmitter transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Slc6a9tm1Jtc/Slc6a9tm1Jtc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1btm1Bbs/?
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hbegftm2Mek/Hbegftm2Mek
Genetic Background: B6.Cg-Hbegftm2Mek

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002634 abnormal sensorimotor gating "malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [J:42758, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a9tm1Jtc/Slc6a9tm1Jtc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atp4btm1Ird/Atp4btm1Ird,Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

 MP:0002888 abnormal NMDA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a9tm1Jtc/Slc6a9tm1Jtc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003234 enhanced NMDA-mediated synaptic currents "increase in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-7H/Pax3Sp-7H
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc6a9tm1Jtc/Slc6a9tm1Jtc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Slc6a9tm1Jtc/Slc6a9+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc6a9tm1Veul/Slc6a9tm1Veul,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Slc6a9tm1Veul/Slc6a9tm1Veul,Tg(Gfap-cre)2Brn/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Slc6a9tm1Veul/Slc6a9tm1Veul,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc6a9tm1Veul/Slc6a9tm1Veul,Tg(Gfap-cre)2Brn/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pdgfrbtm7Sor/Pdgfrbtm7Sor
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Slc6a9tm1Jtc/Slc6a9tm1Jtc
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Slc6a9tm1Veul/Slc6a9tm1Veul,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pax3Sp-7H/Pax3Sp-7H
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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