ENSMUSG00000030307


Mus musculus

Features
Gene ID: ENSMUSG00000030307
  
Biological name :Slc6a11
  
Synonyms : P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3
  
Possible biological names infered from orthology : P48066 / solute carrier family 6 member 11
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 114131241
Gene end: 114249952
  
Corresponding Affymetrix probe sets: 10540822 (MoGene1.0st)   1433989_at (Mouse Genome 430 2.0 Array)   1453871_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032451
NCBI entrez gene - 243616     See in Manteia.
MGI - MGI:95630
RefSeq - NM_172890
RefSeq Peptide - NP_766478
swissprot - P31650
Ensembl - ENSMUSG00000030307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a11bENSDARG00000087981Danio rerio
 SLC6A11ENSGALG00000004879Gallus gallus
 P48066ENSG00000132164Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010865
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010963
O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / P31641* / solute carrier family 6 member 6*ENSMUSG0000003009659
Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8 / P48029* / solute carrier family 6 member 8*ENSMUSG0000001955853
P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1 / P30531* / solute carrier family 6 member 1*ENSMUSG0000003031049
Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5 / Q9Y345* / solute carrier family 6 member 5*ENSMUSG0000003972842
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202641
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536839
Q60857 / Slc6a4 / Sodium-dependent serotonin transporter / P31645* / solute carrier family 6 member 4*ENSMUSG0000002083839
Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) / Q9UN76* / solute carrier family 6 member 14*ENSMUSG0000003108939
P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1 / P48067* / solute carrier family 6 member 9*ENSMUSG0000002854239
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR002982  Sodium:neurotransmitter symporter, GABA, GAT-3
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0015812 gamma-aminobutyric acid transport IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005215 transporter activity IBA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0005332 gamma-aminobutyric acid:sodium symporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0042165 neurotransmitter binding IEA


Pathways (from Reactome)
Pathway description
Na+/Cl- dependent neurotransmitter transporters
Creatine metabolism
Reuptake of GABA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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