ENSMUSG00000020838


Mus musculus

Features
Gene ID: ENSMUSG00000020838
  
Biological name :Slc6a4
  
Synonyms : Q60857 / Slc6a4 / Sodium-dependent serotonin transporter
  
Possible biological names infered from orthology : P31645 / solute carrier family 6 member 4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 76998603
Gene end: 77032340
  
Corresponding Affymetrix probe sets: 10378816 (MoGene1.0st)   1417150_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021195
Ensembl peptide - ENSMUSP00000104039
Ensembl peptide - ENSMUSP00000115264
NCBI entrez gene - 15567     See in Manteia.
MGI - MGI:96285
RefSeq - XM_006532302
RefSeq - NM_010484
RefSeq - XM_006532299
RefSeq - XM_006532300
RefSeq - XM_006532301
RefSeq Peptide - NP_034614
swissprot - Q5NCR5
swissprot - Q60857
Ensembl - ENSMUSG00000020838
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a4aENSDARG00000061165Danio rerio
 SLC6A4ENSGALG00000004246Gallus gallus
 P31645ENSG00000108576Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O55192 / Slc6a2 / solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / P23975* / solute carrier family 6 member 2*ENSMUSG0000005536848
Q61327 / Slc6a3 / Sodium-dependent dopamine transporter / Q01959* / solute carrier family 6 member 3*ENSMUSG0000002160947
Slc6a12 / solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 / P48065* / solute carrier family 6 member 12*ENSMUSG0000003010939
Q8VBW1 / Slc6a8 / solute carrier family 6 (neurotransmitter transporter, creatine), member 8 / P48029* / solute carrier family 6 member 8*ENSMUSG0000001955839
Slc6a5 / solute carrier family 6 (neurotransmitter transporter, glycine), member 5 / Q9Y345* / solute carrier family 6 member 5*ENSMUSG0000003972839
P31650 / Slc6a11 / Sodium- and chloride-dependent GABA transporter 3 / P48066* / solute carrier family 6 member 11*ENSMUSG0000003030739
P31649 / Slc6a13 / Sodium- and chloride-dependent GABA transporter 2 / Q9NSD5* / solute carrier family 6 member 13*ENSMUSG0000003010839
O35316 / Slc6a6 / solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / P31641* / solute carrier family 6 member 6*ENSMUSG0000003009638
Q6PGE7 / Slc6a7 / Sodium-dependent proline transporter / Q99884* / solute carrier family 6 member 7*ENSMUSG0000005202638
P28571 / Slc6a9 / Sodium- and chloride-dependent glycine transporter 1 / P48067* / solute carrier family 6 member 9*ENSMUSG0000002854237
Q9JMA9 / Slc6a14 / Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) / Q9UN76* / solute carrier family 6 member 14*ENSMUSG0000003108937
P31648 / Slc6a1 / Sodium- and chloride-dependent GABA transporter 1 / P30531* / solute carrier family 6 member 1*ENSMUSG0000003031037


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR013086  Sodium:neurotransmitter symporter, serotonin, N-terminal
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006837 serotonin transport IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009636 response to toxic substance ISO
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014064 positive regulation of serotonin secretion IEA
 biological_processGO:0015844 monoamine transport ISO
 biological_processGO:0021941 negative regulation of cerebellar granule cell precursor proliferation IEA
 biological_processGO:0032227 negative regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0035176 social behavior IGI
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0046621 negative regulation of organ growth IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0051259 protein complex oligomerization ISS
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051583 dopamine uptake involved in synaptic transmission IBA
 biological_processGO:0051610 serotonin uptake ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0071321 cellular response to cGMP IEA
 biological_processGO:0090067 regulation of thalamus size ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012505 endomembrane system ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0005330 dopamine:sodium symporter activity IBA
 molecular_functionGO:0005335 serotonin:sodium symporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008504 monoamine transmembrane transporter activity ISO
 molecular_functionGO:0015222 serotonin transmembrane transporter activity ISO
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0017137 Rab GTPase binding ISO
 molecular_functionGO:0019811 cocaine binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IPI
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
Serotonin clearance from the synaptic cleft


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps

Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps

Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Gpc3tm1Arge/Y
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Htr2atm1Grch/Htr2atm2Grch,Slc6a4tm1(cre)Grch/Slc6a4+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Emx2tm1Sia/Emx2tm1Sia,Otx2tm7Sia/Otx2tm7Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Runx1tm4(Runx2)Toku/Runx1tm4(Runx2)Toku
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gpc3tm1Arge/Y
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Gnat3tm1Rfm/Gnat3tm1Rfm
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm4(Runx2)Toku/Runx1tm4(Runx2)Toku
Genetic Background: involves: 129P2/OlaHsd

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpc3tm1Arge/Y
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Slc6a4tm1(SLC6A4)Kres/Slc6a4tm1(SLC6A4)Kres
Genetic Background: involves: C57BL/6

Allelic Composition: Slc6a4tm2(SLC6A4)Kres/Slc6a4tm2(SLC6A4)Kres
Genetic Background: involves: C57BL/6

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps

Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Gnat3tm1Rfm/Gnat3tm1Rfm
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0002635 reduced sensorimotor gating 
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Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gpc3tm1Arge/Y
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Slc6a4tm1(cre)Xz/Slc6a4tm1(cre)Xz
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Gnat1tm1Clma/Gnat1tm1Clma,Gnat3tm1Rfm/Gnat3tm1Rfm
Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: B6.129-Slc6a4tm1Kpl

 MP:0003877 abnormal serotonergic neuron morphology "malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]
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Allelic Composition: Gpc3tm1Arge/Y
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

 MP:0003958 heart valve hyperplasia "increased number of cells of the heart valves, leading to increased size or bulk" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:60214]
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Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Emx2tm1Sia/Emx2tm1Sia,Otx2tm7Sia/Otx2tm7Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Htr1btm1Rhn/Htr1btm1Rhn,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpc3tm1Arge/Y
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Slc6a3tm1Mca/Slc6a3tm1Mca,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Slc6a4tm1Kpl/Slc6a4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc6a4tm1(cre)Xz/Slc6a4tm1(cre)Xz
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011479 abnormal catecholamine level "any anomaly in the amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
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Allelic Composition: Slc18a2tm1.1Bgir/Slc18a2tm1.1Bgir,Slc6a4tm1(cre)Xz/Slc6a4+
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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