ENSG00000165970


Homo sapiens

Features
Gene ID: ENSG00000165970
  
Biological name :SLC6A5
  
Synonyms : Q9Y345 / SLC6A5 / solute carrier family 6 member 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.1
Gene start: 20599400
Gene end: 20659285
  
Corresponding Affymetrix probe sets: 210810_s_at (Human Genome U133 Plus 2.0 Array)   236508_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434364
Ensembl peptide - ENSP00000298923
RefSeq - NM_004211
RefSeq - XM_017018545
RefSeq - NM_001318369
RefSeq - XM_017018544
RefSeq Peptide - NP_004202
RefSeq Peptide - NP_001305298
swissprot - Q9Y345
swissprot - J3KNC4
Ensembl - ENSG00000165970
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc6a5ENSDARG00000067964Danio rerio
 SLC6A5ENSGALG00000003908Gallus gallus
 Slc6a5ENSMUSG00000039728Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UN76 / SLC6A14 / solute carrier family 6 member 14ENSG0000026810441
Q99884 / SLC6A7 / solute carrier family 6 member 7ENSG0000001108339
P48067 / SLC6A9 / solute carrier family 6 member 9ENSG0000019651739
P30531 / SLC6A1 / solute carrier family 6 member 1ENSG0000015710334
P48065 / SLC6A12 / solute carrier family 6 member 12ENSG0000011118134
Q9NSD5 / SLC6A13 / solute carrier family 6 member 13ENSG0000001037934
P48066 / SLC6A11 / solute carrier family 6 member 11ENSG0000013216433
P48029 / SLC6A8 / solute carrier family 6 member 8ENSG0000013082132
P31641 / SLC6A6 / solute carrier family 6 member 6ENSG0000013138932
Q01959 / SLC6A3 / solute carrier family 6 member 3ENSG0000014231932
P31645 / SLC6A4 / solute carrier family 6 member 4ENSG0000010857631
P23975 / SLC6A2 / solute carrier family 6 member 2ENSG0000010354631


Protein motifs (from Interpro)
Interpro ID Name
 IPR000175  Sodium:neurotransmitter symporter
 IPR037272  Sodium:neurotransmitter symporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0015816 glycine transport IEA
 biological_processGO:0060012 synaptic transmission, glycinergic IMP
 biological_processGO:1903804 glycine import across plasma membrane IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0005328 neurotransmitter:sodium symporter activity IEA
 molecular_functionGO:0015187 glycine transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015375 glycine:sodium symporter activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Na+/Cl- dependent neurotransmitter transporters
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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