ENSGALG00000008756


Gallus gallus

Features
Gene ID: ENSGALG00000008756
  
Biological name :PLEK
  
Synonyms : pleckstrin / PLEK
  
Possible biological names infered from orthology : P08567 / Q9JHK5
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 11341790
Gene end: 11356873
  
Corresponding Affymetrix probe sets: Gga.392.1.S1_at (Chicken Array)   Gga.392.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014229
NCBI entrez gene - 395669     See in Manteia.
RefSeq - NM_204863
RefSeq Peptide - NP_990194
swissprot - F1NSA0
Ensembl - ENSGALG00000008756
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekENSDARG00000104325Danio rerio
 PLEKENSG00000115956Homo sapiens
 PlekENSMUSG00000020120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLEK2 / Q9NYT0* / Q9WV52* / pleckstrin 2*ENSGALG0000000956241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001849  Pleckstrin homology domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0002576 platelet degranulation IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010572 positive regulation of platelet activation IEA
 biological_processGO:0010920 negative regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0010925 positive regulation of inositol-polyphosphate 5-phosphatase activity IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IEA
 biological_processGO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0031529 ruffle organization IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IEA
 biological_processGO:0033625 positive regulation of integrin activation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0060305 regulation of cell diameter IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0070560 protein secretion by platelet IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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