ENSMUSG00000020120


Mus musculus

Features
Gene ID: ENSMUSG00000020120
  
Biological name :Plek
  
Synonyms : pleckstrin / Plek / Q9JHK5
  
Possible biological names infered from orthology : P08567
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A2
Gene start: 16971206
Gene end: 17052381
  
Corresponding Affymetrix probe sets: 10384458 (MoGene1.0st)   1417523_at (Mouse Genome 430 2.0 Array)   1448748_at (Mouse Genome 430 2.0 Array)   1448749_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020321
Ensembl peptide - ENSMUSP00000099945
Ensembl peptide - ENSMUSP00000122225
NCBI entrez gene - 56193     See in Manteia.
MGI - MGI:1860485
RefSeq - NM_019549
RefSeq Peptide - NP_062422
swissprot - Q5F270
swissprot - Q5F271
swissprot - Q8CAG6
swissprot - Q9JHK5
Ensembl - ENSMUSG00000020120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekENSDARG00000104325Danio rerio
 PLEKENSGALG00000008756Gallus gallus
 PLEKENSG00000115956Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plek2 / Q9WV52 / Pleckstrin-2 / Q9NYT0*ENSMUSG0000002111836


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037370  Pleckstrin
 IPR037371  Pleckstrin 1, DEP domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0002576 platelet degranulation IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010572 positive regulation of platelet activation IMP
 biological_processGO:0010920 negative regulation of inositol phosphate biosynthetic process ISO
 biological_processGO:0010925 positive regulation of inositol-polyphosphate 5-phosphatase activity ISO
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IMP
 biological_processGO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway ISO
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0031529 ruffle organization IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IEA
 biological_processGO:0033625 positive regulation of integrin activation IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0060305 regulation of cell diameter ISO
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IMP
 biological_processGO:0070527 platelet aggregation IMP
 biological_processGO:0070528 protein kinase C signaling IMP
 biological_processGO:0070560 protein secretion by platelet IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty,Phlda3tm1Bty/Phlda3tm1Bty
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty,Phlda3tm1Bty/Phlda3tm1Bty
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty,Phlda3tm1Bty/Phlda3tm1Bty
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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