ENSG00000115956


Homo sapiens

Features
Gene ID: ENSG00000115956
  
Biological name :PLEK
  
Synonyms : P08567 / pleckstrin / PLEK
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p14
Gene start: 68365173
Gene end: 68397453
  
Corresponding Affymetrix probe sets: 203470_s_at (Human Genome U133 Plus 2.0 Array)   203471_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000234313
NCBI entrez gene - 5341     See in Manteia.
OMIM - 173570
RefSeq - NM_002664
RefSeq Peptide - NP_002655
swissprot - P08567
Ensembl - ENSG00000115956
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekENSDARG00000104325Danio rerio
 PLEKENSGALG00000008756Gallus gallus
 PlekENSMUSG00000020120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLEK2 / Q9NYT0 / pleckstrin 2ENSG0000010055838


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037370  Pleckstrin
 IPR037371  Pleckstrin 1, DEP domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEP
 biological_processGO:0002576 platelet degranulation IEP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0010572 positive regulation of platelet activation IEA
 biological_processGO:0010920 negative regulation of inositol phosphate biosynthetic process IDA
 biological_processGO:0010925 positive regulation of inositol-polyphosphate 5-phosphatase activity IDA
 biological_processGO:0030030 cell projection organization IDA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IDA
 biological_processGO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0030866 cortical actin cytoskeleton organization IDA
 biological_processGO:0031529 ruffle organization IDA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IDA
 biological_processGO:0033625 positive regulation of integrin activation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0046488 phosphatidylinositol metabolic process IDA
 biological_processGO:0050849 negative regulation of calcium-mediated signaling NAS
 biological_processGO:0060305 regulation of cell diameter IDA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IDA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0070560 protein secretion by platelet IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032587 ruffle membrane IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0005080 protein kinase C binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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