ENSGALG00000014873


Gallus gallus

Features
Gene ID: ENSGALG00000014873
  
Biological name :GJA1
  
Synonyms : gap junction alpha-1 protein / GJA1
  
Possible biological names infered from orthology : gap junction protein alpha 1 / P17302 / P23242
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 61930601
Gene end: 61938188
  
Corresponding Affymetrix probe sets: GgaAffx.21790.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023950
NCBI entrez gene - 395278     See in Manteia.
RefSeq - NM_204586
RefSeq Peptide - NP_989917
swissprot - F1N9K3
Ensembl - ENSGALG00000014873
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cx40.8ENSDARG00000071192Danio rerio
 GJA1ENSG00000152661Homo sapiens
 Gja1ENSMUSG00000050953Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GJA3 / P29415 / Gap junction alpha-3 protein / Q64448* / Q9Y6H8* / gap junction protein alpha 3*ENSGALG0000001713746
GJA4 / gap junction protein alpha 4 / P28235* / P35212*ENSGALG0000000253243
GJA8 / gap junction alpha-8 protein / P28236* / P48165* / gap junction protein alpha 8*ENSGALG0000001548841
GJA5 / P36382* / Q01231* / gap junction protein alpha 5*ENSGALG0000003945239
GJA10 / gap junction protein alpha 10 / Q969M2* / Q9WUS4*ENSGALG0000001560636
GJA9 / gap junction protein alpha 9 / P57773*ENSGALG0000002817535
GJA5* / P36382* / Q01231* / gap junction protein alpha 5*ENSGALG0000004273535
GJC2 / gap junction protein gamma 2 / Q5T442* / Q8BQU6*ENSGALG0000000533131
ENSGALG0000004292930
GJC1 / P18861 / Gap junction gamma-1 protein / P28229* / P36383* / gap junction protein gamma 1*ENSGALG0000000099730
ENSGALG0000001123328
GJD2 / gap junction protein delta 2 / O54851* / Q9UKL4*ENSGALG0000000984525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002261  Gap junction alpha-1 protein (Cx43)
 IPR013092  Connexin, N-terminal
 IPR013124  Gap junction alpha-1 protein (Cx43), C-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002070 epithelial cell maturation IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0003294 atrial ventricular junction remodeling IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010643 cell communication by chemical coupling IEA
 biological_processGO:0010644 cell communication by electrical coupling IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035050 embryonic heart tube development IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045844 positive regulation of striated muscle tissue development IEA
 biological_processGO:0046850 regulation of bone remodeling IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0060156 milk ejection reflex IEA
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IEA
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization IEA
 biological_processGO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization IEA
 biological_processGO:0061337 cardiac conduction IEA
 biological_processGO:0071467 cellular response to pH IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005916 fascia adherens IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043292 contractile fiber IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0015075 ion transmembrane transporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA
 molecular_functionGO:1903763 gap junction channel activity involved in cell communication by electrical coupling IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
Gap junction degradation
c-src mediated regulation of Cx43 function and closure of gap junctions
Formation of annular gap junctions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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