ENSMUSG00000050953


Mus musculus

Features
Gene ID: ENSMUSG00000050953
  
Biological name :Gja1
  
Synonyms : gap junction protein, alpha 1 / Gja1 / P23242
  
Possible biological names infered from orthology : P17302
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 56377330
Gene end: 56402513
  
Corresponding Affymetrix probe sets: 10363173 (MoGene1.0st)   1415800_at (Mouse Genome 430 2.0 Array)   1415801_at (Mouse Genome 430 2.0 Array)   1437992_x_at (Mouse Genome 430 2.0 Array)   1438650_x_at (Mouse Genome 430 2.0 Array)   1438945_x_at (Mouse Genome 430 2.0 Array)   1438973_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151620
Ensembl peptide - ENSMUSP00000151974
Ensembl peptide - ENSMUSP00000151647
Ensembl peptide - ENSMUSP00000064536
Ensembl peptide - ENSMUSP00000151596
Ensembl peptide - ENSMUSP00000151603
NCBI entrez gene - 14609     See in Manteia.
MGI - MGI:95713
RefSeq - NM_010288
RefSeq Peptide - NP_034418
swissprot - A0A1W2P8A3
swissprot - A0A1W2P793
swissprot - P23242
Ensembl - ENSMUSG00000050953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cx40.8ENSDARG00000071192Danio rerio
 GJA1ENSGALG00000014873Gallus gallus
 GJA1ENSG00000152661Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gja6 / Q6S5G4 / gap junction protein, alpha 6ENSMUSG0000005569149
Gja3 / Q64448 / gap junction protein, alpha 3 / Q9Y6H8*ENSMUSG0000004858243
Gja8 / P28236 / gap junction protein, alpha 8 / P48165*ENSMUSG0000004990840
Gja4 / P28235 / gap junction protein, alpha 4 / P35212*ENSMUSG0000005023440
Gja5 / Q01231 / gap junction protein, alpha 5 / P36382*ENSMUSG0000005712335
Gja10 / Q9WUS4 / gap junction protein, alpha 10 / Q969M2*ENSMUSG0000005105634
Gjc1 / P28229 / gap junction protein, gamma 1 / P36383*ENSMUSG0000003452031
Gjc2 / Q8BQU6 / gap junction protein, gamma 2 / Q5T442*ENSMUSG0000004344830
Gjd2 / O54851 / gap junction protein, delta 2 / Q9UKL4*ENSMUSG0000006861525
Gjd3 / Q91YD1 / gap junction protein, delta 3 / Q8N144*ENSMUSG0000004719724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002261  Gap junction alpha-1 protein (Cx43)
 IPR013092  Connexin, N-terminal
 IPR013124  Gap junction alpha-1 protein (Cx43), C-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain
 IPR034634  Connexin, C-terminal
 IPR035091  Gap junction alpha-1 protein (Cx43), alpha helix domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002070 epithelial cell maturation IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0003104 positive regulation of glomerular filtration IEA
 biological_processGO:0003158 endothelium development IEA
 biological_processGO:0003294 atrial ventricular junction remodeling IGI
 biological_processGO:0003347 epicardial cell to mesenchymal cell transition TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007267 cell-cell signaling ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007512 adult heart development IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010232 vascular transport IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010643 cell communication by chemical coupling IDA
 biological_processGO:0010644 cell communication by electrical coupling IEA
 biological_processGO:0010652 positive regulation of cell communication by chemical coupling IEA
 biological_processGO:0015867 ATP transport IEA
 biological_processGO:0022898 regulation of transmembrane transporter activity IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030500 regulation of bone mineralization IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043403 skeletal muscle tissue regeneration IDA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045216 cell-cell junction organization IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045844 positive regulation of striated muscle tissue development IMP
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060156 milk ejection reflex IMP
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IMP
 biological_processGO:0060312 regulation of blood vessel remodeling TAS
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization IMP
 biological_processGO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization IMP
 biological_processGO:0061045 negative regulation of wound healing IEA
 biological_processGO:0061337 cardiac conduction IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071374 cellular response to parathyroid hormone stimulus IEA
 biological_processGO:0071467 cellular response to pH IDA
 biological_processGO:0086064 cell communication by electrical coupling involved in cardiac conduction IEA
 biological_processGO:0090162 establishment of epithelial cell polarity TAS
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1905867 epididymis development IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 biological_processGO:2000810 regulation of bicellular tight junction assembly IEA
 biological_processGO:2000987 positive regulation of behavioral fear response IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005882 intermediate filament IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005916 fascia adherens IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043292 contractile fiber IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015075 ion transmembrane transporter activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IDA
 molecular_functionGO:0071253 connexin binding IEA
 molecular_functionGO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling TAS
 molecular_functionGO:0097110 scaffold protein binding IPI
 molecular_functionGO:0097718 disordered domain specific binding IEA
 molecular_functionGO:1903763 gap junction channel activity involved in cell communication by electrical coupling IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
Gap junction degradation
c-src mediated regulation of Cx43 function and closure of gap junctions
Formation of annular gap junctions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr,Tg(CMV-Gja1)BClo/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SJL/J * SWR/J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Fut4tm1Jbl/Fut4tm1Jbl,Fut7tm1Jbl/Fut7tm1Jbl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Gja1Gt(ROSANBetageo)15C3Masn/Gja1Gt(ROSANBetageo)15C3Masn
Genetic Background: involves: 129P2/OlaHsd

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr,Tg(CMV-Gja1)BClo/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SJL/J * SWR/J

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gja1tm1.1Gfi/Gja1tm1.1Gfi
Genetic Background: Not Specified

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0000448 pointed snout "nose tapers to a small tip, sharper angle than wild type " [J:18378]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000884 delaminated Purkinje cell layer "splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0000887 delaminated granule layer "splitting or disorganization of the deepest of the three layers of the cerebellum that contains granule cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001319 irregularly shaped pupil "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001443 poor grooming "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(Prrx1-FUS/DDIT3)1Mete/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm3.3(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc45a2uw-6Btlr/Slc45a2uw-6Btlr
Genetic Background: C57BL/6J-Slc45a2uw-6Btlr

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhtm1Maj/Crhtm1Maj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Gja1tm1Gfi/Gja1tm1Gfi,Myl2tm1(cre)Krc/Myl2+
Genetic Background: Not Specified

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr,Tg(CMV-Gja1)BClo/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SJL/J * SWR/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Gja1tm1Kdr/Gja1tm1Kwi,Tg(Tek-cre)5326Sato/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Gja1tm6(Gjb3)Kwi/Gja1tm6(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002336 abnormal pulmonary gas exchange "anomaly in the exchange of oxygen and carbon dioxide between the alveolar air and pulmonary capillary blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gja1tm1.1Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002577 reduced enamel thickness "thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002748 abnormal pulmonary valve morphology "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Wastm1Sbs/Wastm1Sbs
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0002776 Sertoli cell hyperplasia "increased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Gja1tm4Kwi/Gja1tm4Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1tm5Gfi/Gja1tm5Gfi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003108 short zygomatic bone "reduced length of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

Allelic Composition: Gja1tm1Kdr/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gja1tm4Gfi/Gja1tm4Gfi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm4Kwi/Gja1tm4Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003235 abnormal alisphenoid bone morphology "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003356 impaired lutenization "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075]
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Allelic Composition: Gja1tm4Kwi/Gja1tm4Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm3.3(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Tg(Mnx1-EGFP)#Tmj/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2tm1Kmi
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003838 abnormal milk ejection "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2tm1Kmi
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gja1tm1.1Gfi/Gja1tm1.1Gfi
Genetic Background: Not Specified

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0003900 shortened QT interval "decrease in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003930 abnormal tooth hard tissue morphology "defects in the hard portion of the tooth surrounding the pulp, including the dentin, enamel and the cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gja1tm1.1Gfi/Gja1tm1.1Gfi
Genetic Background: Not Specified

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

Allelic Composition: Gja1tm1Kdr/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gja1tm1.1Gfi/Gja1+
Genetic Background: Not Specified

 MP:0004116 abnormal atrioventricular bundle conduction "anomaly in the transfer of cardiac electrical impulses through the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004225 patent foramen ovale "incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0004377 small frontal bone "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0004385 interparietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0004469 abnormal zygomatic arch morphology "any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0004470 small nasal bone "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0004540 small maxilla "reduced size of the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1.1Beis/Gja1tm1.1Beis
Genetic Background: B6.Cg-Gja1tm1.1Beis

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd80tm1Shr/Cd80tm1Shr,Cd86tm2Shr/Cd86tm2Shr
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm4Kwi/Gja1tm4Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Gja1tm1.1Beis/Gja1tm1.1Beis
Genetic Background: B6.Cg-Gja1tm1.1Beis

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0006049 semilunar valve insufficiency "the semilunar valves do not close tightly enough to prevent leakage." [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0006110 ventricular fibrillation "asynchronous contraction or quivering of individual cardiac muscle fibers in the ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Gja1tm1.1Gfi/Gja1tm1.1Gfi
Genetic Background: Not Specified

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2tm1Kmi
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0009732 ventricular premature beat "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

 MP:0010194 absent lymphatic vessels "absence of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gjb2tm3.3(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gja1M1Jrt/Gja1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/N

Allelic Composition: Gja1tm1Kdr/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010394 decreased QRS amplitude "reduction in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010428 abnormal heart right ventricle outflow tract morphology "any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gja1tm1.1Gfi/Gja1tm1.1Gfi
Genetic Background: Not Specified

 MP:0010449 heart right ventricle outflow tract stenosis "abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010453 abnormal coronary vein morphology "any structural anomaly of any of the veins that return blood from the heart muscles to the right atrium through the coronary sinus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0010472 abnormal ascending aorta and coronary artery attachment "any anomaly of the connection site of any or all of the coronary arteries to the ascending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bfsp1tm1Pgf/Bfsp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010476 coronary fistula "an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or any segment of the systemic or pulmonary circulation (coronary arteriovenous fistula)" [http://emedicine.medscape.com]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0010477 coronary artery aneurysm "a protruding sac formed by the dilation of the wall of a coronary artery resulting from a weakening of the vessel wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gja1tm4Kwi/Gja1tm4Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm1.1Kwi/Gja1tm4Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1tm2(Gjb1)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1tm3(Gja5)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja1tm1Gfi/Gja1tm1.1Gfi,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Gja1tm1.1Kwi/Gja1tm1.1Kwi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gja1tm1Kdr/Gja1tm1.1Kwi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

Allelic Composition: Gja1tm10Kwi/Gja1tm10Kwi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gja1Gt(ROSANBetageo)15C3Masn/Gja1Gt(ROSANBetageo)15C3Masn
Genetic Background: involves: 129P2/OlaHsd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gja1tm6.1(Gjb3)Kwi/Gja1tm6.1(Gjb3)Kwi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gjb2tm3.3(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tbx4tm1.1Kng/Tbx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Myctm1Slek/Myctm1Slek
Genetic Background: involves: 129

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gja1tm3Gfi/Gja1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Gja1tm1Dlg/Gja1tm1Dlg,Tg(GFAP-cre)1Kdmc/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J

 MP:0011919 abnormal R wave "any anomaly in the R wave which represents ventricular depolarization and corresponds to electrical impulses rather than mechanical ventricular contractions; irregular or multiple R waves may indicate arrhythmia and the shape of the R waves may indicate ventricular problems" [MPD:Molly]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0013781 abnormal mammary gland luminal epithelium morphology "any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective tissue; they are secretory epithelial cells characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin" [http://umr144.curie.fr/en/research-groups/molecular-mechanisms-mammary-gland-development-marina-glukhova/molecular-mechanisms-, ISBN:8793237073, MGI:Anna]
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Allelic Composition: Gja1tm2(Gjb1)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030034 depressed nasal bridge "posterior positioning of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose in relation to the overall facial profile for age; normally, it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [HP:0005280]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0030064 small face "presence of an abnormally small face" [MGI:anna]
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Allelic Composition: Gja1tm8Kwi/Gja1+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0030080 small lower incisors "reduced size of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0030190 small snout "decreased size of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0030281 thin parietal bone "reduced thickness of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [MGI:anna]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

 MP:0030315 small neurocranium "decreased size of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000030516 Tjp1 / P39447 / tight junction protein 1 / Q07157*  / complex
 ENSMUSG00000050953 Gja1 / P23242 / gap junction protein, alpha 1 / P17302*  / complex






 

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