ENSMUSG00000057123


Mus musculus

Features
Gene ID: ENSMUSG00000057123
  
Biological name :Gja5
  
Synonyms : gap junction protein, alpha 5 / Gja5 / Q01231
  
Possible biological names infered from orthology : P36382
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 96904693
Gene end: 97077416
  
Corresponding Affymetrix probe sets: 10494548 (MoGene1.0st)   1422192_at (Mouse Genome 430 2.0 Array)   1429101_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088264
Ensembl peptide - ENSMUSP00000123582
Ensembl peptide - ENSMUSP00000143542
NCBI entrez gene - 14613     See in Manteia.
MGI - MGI:95716
RefSeq - NM_008121
RefSeq - NM_001271628
RefSeq Peptide - NP_001258557
RefSeq Peptide - NP_032147
swissprot - Q01231
swissprot - Q6TPI9
swissprot - Q8CAG8
Ensembl - ENSMUSG00000057123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gja5aENSDARG00000040065Danio rerio
 gja5bENSDARG00000069450Danio rerio
 ENSGALG00000042735Gallus gallus
 GJA5ENSGALG00000039452Gallus gallus
 GJA5ENSG00000265107Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gja8 / P28236 / gap junction protein, alpha 8 / P48165*ENSMUSG0000004990844
Gja3 / Q64448 / gap junction protein, alpha 3 / Q9Y6H8*ENSMUSG0000004858243
Gja4 / P28235 / gap junction protein, alpha 4 / P35212*ENSMUSG0000005023438
Gja10 / Q9WUS4 / gap junction protein, alpha 10 / Q969M2*ENSMUSG0000005105638
Gja1 / P23242 / gap junction protein, alpha 1 / P17302*ENSMUSG0000005095337
Gjc2 / Q8BQU6 / gap junction protein, gamma 2 / Q5T442*ENSMUSG0000004344834
Gja6 / Q6S5G4 / gap junction protein, alpha 6ENSMUSG0000005569132
Gjc1 / P28229 / gap junction protein, gamma 1 / P36383*ENSMUSG0000003452032
Gjd2 / O54851 / gap junction protein, delta 2 / Q9UKL4*ENSMUSG0000006861531
Gjd3 / Q91YD1 / gap junction protein, delta 3 / Q8N144*ENSMUSG0000004719727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002264  Gap junction alpha-5 protein (Cx40)
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain
 IPR031862  Gap junction alpha-5 protein (Cx40), C-terminal
 IPR034634  Connexin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0003071 renal system process involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0003073 regulation of systemic arterial blood pressure IMP
 biological_processGO:0003105 negative regulation of glomerular filtration IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003158 endothelium development IEA
 biological_processGO:0003161 cardiac conduction system development IMP
 biological_processGO:0003174 mitral valve development IEA
 biological_processGO:0003193 pulmonary valve formation IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0003283 atrial septum development IEA
 biological_processGO:0003284 septum primum development IMP
 biological_processGO:0003294 atrial ventricular junction remodeling IMP
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010643 cell communication by chemical coupling IEA
 biological_processGO:0010644 cell communication by electrical coupling IEA
 biological_processGO:0010652 positive regulation of cell communication by chemical coupling IEA
 biological_processGO:0016264 gap junction assembly IEA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035922 foramen ovale closure IMP
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IMP
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization IEA
 biological_processGO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060413 atrial septum morphogenesis IMP
 biological_processGO:0061337 cardiac conduction IMP
 biological_processGO:0086005 ventricular cardiac muscle cell action potential IMP
 biological_processGO:0086015 SA node cell action potential IMP
 biological_processGO:0086044 atrial cardiac muscle cell to AV node cell communication by electrical coupling IMP
 biological_processGO:0086053 AV node cell to bundle of His cell communication by electrical coupling IEA
 biological_processGO:0086054 bundle of His cell to Purkinje myocyte communication by electrical coupling IEA
 biological_processGO:0086064 cell communication by electrical coupling involved in cardiac conduction IEA
 biological_processGO:0086065 cell communication involved in cardiac conduction IMP
 biological_processGO:0086067 AV node cell to bundle of His cell communication IMP
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IMP
 biological_processGO:0097746 regulation of blood vessel diameter IMP
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:0098904 regulation of AV node cell action potential IEA
 biological_processGO:0098905 regulation of bundle of His cell action potential IMP
 biological_processGO:0098906 regulation of Purkinje myocyte action potential IEA
 biological_processGO:0098910 regulation of atrial cardiac muscle cell action potential IEA
 biological_processGO:1900133 regulation of renin secretion into blood stream IMP
 biological_processGO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential IMP
 biological_processGO:1990029 vasomotion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex ISO
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0055077 gap junction hemi-channel activity IEA
 molecular_functionGO:0071253 connexin binding IEA
 molecular_functionGO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling IEA
 molecular_functionGO:0086076 gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling IEA
 molecular_functionGO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling IEA
 molecular_functionGO:0086078 gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling IEA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Gap junction assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Thbdtm1Rdr/Thbdtm1Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Thbdtm1Rdr/Thbdtm1Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1Gfi,Myl2tm1(cre)Krc/Myl2+
Genetic Background: Not Specified

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1Gfi,Myl2tm1(cre)Krc/Myl2+
Genetic Background: Not Specified

Allelic Composition: Gja5tm1(Gja7)Hvr/Gja5tm1(Gja7)Hvr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004072 abnormal frontal plane axis "any anomaly found in the sum of all electrical currents in the heart during systole" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0004253 bifid atrial appendage "a cardiac anomaly whereby the left or right atrial appendage is cleaved, forming two separate pouches connected by a thin strand of muscular tissue" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gja5tm1Mchn/Gja5tm1Mchn,Tg(TIE2-lacZ)182Sato/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gja5tm1Mchn/Gja5tm1Mchn,Tg(TIE2-lacZ)182Sato/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0006122 mitral valve stenosis "abnormal narrowing of the mitral valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1Gfi,Myl2tm1(cre)Krc/Myl2+
Genetic Background: Not Specified

Allelic Composition: Gja5tm1(Gja7)Hvr/Gja5tm1(Gja7)Hvr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0010460 pulmonary artery hypoplasia "underdevelopment or reduced size of the artery that arises from the right ventricle and conveys unaerated blood to the lungs, usually due to reduced cell number" [MESH:A07.231.114.715]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0010464 abnormal aortic arch and aortic arch branch attachment "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Gja1tm1Gfi/Gja1tm1Gfi,Myl2tm1(cre)Krc/Myl2+
Genetic Background: Not Specified

Allelic Composition: Gja5tm1(Gja7)Hvr/Gja5tm1(Gja7)Hvr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010514 fragmented QRS complex "changes in QRS waveform pattern including different RSR patterns, additional R waves, notched or absent Q or S wave, or more than one R wave" [PMID:20186984]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1crv4/Grm1crv4
Genetic Background: BALB/cPas-Grm1crv4

 MP:0010636 bundle branch block "intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gja5tm1Mchn/Gja5tm1Mchn,Tg(TIE2-lacZ)182Sato/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011953 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
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Allelic Composition: Gja5tm1Kwi/Gja5tm1Kwi
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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