ENSMUSG00000048582


Mus musculus

Features
Gene ID: ENSMUSG00000048582
  
Biological name :Gja3
  
Synonyms : gap junction protein, alpha 3 / Gja3 / Q64448
  
Possible biological names infered from orthology : Q9Y6H8
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 57034460
Gene end: 57058100
  
Corresponding Affymetrix probe sets: 10420359 (MoGene1.0st)   1422339_at (Mouse Genome 430 2.0 Array)   1439793_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059587
Ensembl peptide - ENSMUSP00000152898
NCBI entrez gene - 14611     See in Manteia.
MGI - MGI:95714
RefSeq - XM_011244959
RefSeq - NM_001271623
RefSeq - NM_016975
RefSeq Peptide - NP_058671
RefSeq Peptide - NP_001258552
swissprot - Q64448
swissprot - Q6TPJ1
Ensembl - ENSMUSG00000048582
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gja3ENSDARG00000021889Danio rerio
 GJA3ENSGALG00000017137Gallus gallus
 GJA3ENSG00000121743Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gja8 / P28236 / gap junction protein, alpha 8 / P48165*ENSMUSG0000004990845
Gja1 / P23242 / gap junction protein, alpha 1 / P17302*ENSMUSG0000005095339
Gja5 / Q01231 / gap junction protein, alpha 5 / P36382*ENSMUSG0000005712337
Gja4 / P28235 / gap junction protein, alpha 4 / P35212*ENSMUSG0000005023436
Gja10 / Q9WUS4 / gap junction protein, alpha 10 / Q969M2*ENSMUSG0000005105634
Gjc1 / P28229 / gap junction protein, gamma 1 / P36383*ENSMUSG0000003452030
Gja6 / Q6S5G4 / gap junction protein, alpha 6ENSMUSG0000005569129
Gjc2 / Q8BQU6 / gap junction protein, gamma 2 / Q5T442*ENSMUSG0000004344829
Gjd2 / O54851 / gap junction protein, delta 2 / Q9UKL4*ENSMUSG0000006861526
Gjd3 / Q91YD1 / gap junction protein, delta 3 / Q8N144*ENSMUSG0000004719724


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002262  Gap junction alpha-3 protein (Cx46)
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain
 IPR034634  Connexin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005243 gap junction channel activity IEA


Pathways (from Reactome)
Pathway description
Gap junction assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Gja8L1/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8L1/Gja8+
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6J

Allelic Composition: Gja3tm1.1Vmb/Gja3tm1.1Vmb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gja3tm1.1Vmb/Gja3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Gja3tm1.1Vmb/Gja3tm1.1Vmb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gja3tm1.1Vmb/Gja3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8L1/Gja8+
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6J

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8L1/Gja8tm1Scr
Genetic Background: involves: 129 * C3H/HeJ * C57BL/6J

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8tm1Scr/Gja8tm1Scr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Gja3tm1Scr/Gja3tm1Scr,Gja8R205G/Gja8R205G
Genetic Background: involves: 129S4/SvJae * CWD/LeAgl * SJL/J

Allelic Composition: Gja3tm1.1Vmb/Gja3tm1.1Vmb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gja3tm1.1Vmb/Gja3+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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