ENSMUSG00000050234


Mus musculus

Features
Gene ID: ENSMUSG00000050234
  
Biological name :Gja4
  
Synonyms : gap junction protein, alpha 4 / Gja4 / P28235
  
Possible biological names infered from orthology : P35212
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 127311421
Gene end: 127314039
  
Corresponding Affymetrix probe sets: 10516481 (MoGene1.0st)   1416255_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062320
NCBI entrez gene - 14612     See in Manteia.
MGI - MGI:95715
RefSeq - NM_008120
RefSeq Peptide - NP_032146
swissprot - P28235
swissprot - Q3UPZ2
Ensembl - ENSMUSG00000050234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cx39.4ENSDARG00000070357Danio rerio
 GJA4ENSGALG00000002532Gallus gallus
 GJA4ENSG00000187513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gja1 / P23242 / gap junction protein, alpha 1 / P17302*ENSMUSG0000005095346
Gja3 / Q64448 / gap junction protein, alpha 3 / Q9Y6H8*ENSMUSG0000004858245
Gja8 / P28236 / gap junction protein, alpha 8 / P48165*ENSMUSG0000004990843
Gja5 / Q01231 / gap junction protein, alpha 5 / P36382*ENSMUSG0000005712341
Gja10 / Q9WUS4 / gap junction protein, alpha 10 / Q969M2*ENSMUSG0000005105640
Gja6 / Q6S5G4 / gap junction protein, alpha 6ENSMUSG0000005569136
Gjc2 / Q8BQU6 / gap junction protein, gamma 2 / Q5T442*ENSMUSG0000004344835
Gjc1 / P28229 / gap junction protein, gamma 1 / P36383*ENSMUSG0000003452035
Gjd2 / O54851 / gap junction protein, delta 2 / Q9UKL4*ENSMUSG0000006861533
Gjd3 / Q91YD1 / gap junction protein, delta 3 / Q8N144*ENSMUSG0000004719728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002263  Gap junction alpha-4 protein (Cx37)
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0003158 endothelium development IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0048265 response to pain IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA


Pathways (from Reactome)
Pathway description
Gap junction assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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