ENSMUSG00000047197


Mus musculus

Features
Gene ID: ENSMUSG00000047197
  
Biological name :Gjd3
  
Synonyms : gap junction protein, delta 3 / Gjd3 / Q91YD1
  
Possible biological names infered from orthology : Q8N144
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98982180
Gene end: 98983016
  
Corresponding Affymetrix probe sets: 10390705 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000055246
NCBI entrez gene - 353155     See in Manteia.
MGI - MGI:2384150
RefSeq - NM_178596
RefSeq Peptide - NP_848711
swissprot - Q91YD1
Ensembl - ENSMUSG00000047197
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GJD3ENSG00000183153Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gjd2 / O54851 / gap junction protein, delta 2 / Q9UKL4*ENSMUSG0000006861537
Gja3 / Q64448 / gap junction protein, alpha 3 / Q9Y6H8*ENSMUSG0000004858236
Gjc2 / Q8BQU6 / gap junction protein, gamma 2 / Q5T442*ENSMUSG0000004344835
Gja8 / P28236 / gap junction protein, alpha 8 / P48165*ENSMUSG0000004990835
Gja5 / Q01231 / gap junction protein, alpha 5 / P36382*ENSMUSG0000005712335
Gja4 / P28235 / gap junction protein, alpha 4 / P35212*ENSMUSG0000005023433
Gja1 / P23242 / gap junction protein, alpha 1 / P17302*ENSMUSG0000005095333
Gjc1 / P28229 / gap junction protein, gamma 1 / P36383*ENSMUSG0000003452032
Gja10 / Q9WUS4 / gap junction protein, alpha 10 / Q969M2*ENSMUSG0000005105632
Gja6 / Q6S5G4 / gap junction protein, alpha 6ENSMUSG0000005569129


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0016264 gap junction assembly ISS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0086053 AV node cell to bundle of His cell communication by electrical coupling IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex ISS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005216 ion channel activity IGI
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling IMP


Pathways (from Reactome)
Pathway description
Gap junction assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006141 abnormal atrioventricular node conduction "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle " [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Genetic Background: involves: 129S/SvEv

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Kwi,Gjd3tm2.1Kwi/Gjd3tm2.1Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0010511 shortened PR interval "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Genetic Background: involves: 129S/SvEv

 MP:0011953 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
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Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Kwi,Gjd3tm2.1Kwi/Gjd3tm2.1Kwi,Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011954 shortened PQ interval "decrease in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
Show

Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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